戴建威
发布时间:2022-03-17

招生专业:生物学(生物化学与分子生物学)

戴建威:博士教授,博士研究生导师

广州医科大学生命科学学院副院长,中国康复医学会修复重建外科专业委员会再生医学转化组委员,广东省生物化学与分子生物学学会理事,呼吸病国家重点实验室PI

email: daijw@gzhmu.edu.cn


教育经历

2005年毕业于吉林大学并获生物化学与分子生物学硕士学位;

2008年毕业于吉林大学并获生物化学与分子生物学博士学位;


研究方向:表观遗传学(非编码RNARNA甲基化)调控PM2.5诱发的呼吸道疾病研究


个人简述:

美国加州大学洛杉矶分校(UCLA)访问学者广州市优秀教师,广东省千百十第六批校级培养对象,广州医科大学 “高水平大学建设学术骨干人才”,“高水平大学建设创新团队”成员;着重关注非编码RNA参与调控PM2.5暴露诱发心肺功能紊乱方面的研究1.已证实空气中的细颗粒物(PM2.5)浓度短期升高能诱发心律失常、加重心衰、激发急性动脉粥样硬化和缺血性心肌病2.PM2.5诱发肺部疾病中肺泡修复异常机制;3.大气环境因素对包括SARS-CoV2在内病毒传播的影响及干预措施。


主持课题情况

1. 国家自然科学基金委员会重点项目, 《大气环境条件对病毒传播的影响机制》, 300万元,2022/01-2026/12,合作单位负责人

2. 广东省自然科学基金面上项目,2021A1515010913,《METTL16介导m6A饰在PM2.5诱发COPD肺微血管损伤中的作用及机制研究》,2021/01-2023/12,主持

3. 国家自然科学基金专项项目,42041002,《病毒气溶胶感染活性在大气传播过程中的演变规律》,2020/04-2020/12,主持

4. 广东省自然科学基金自由申请项目,2018A0303130281,《PM2.5通过miR-21靶向网络诱发COPD探究》,2018/05-2021/04,主持

5. 广东省科技计划项目,2017A020211009穿心莲内酯及其衍生物作为肿瘤血管新生靶向药物的研究与开发》,2017/1-2019/12,主持

6. 广东省自然科学基金自由申请项目,1614050002624,《lncRNA HCG18-miR-21网络在PM2.5诱发血管内皮通透性增加中的作用及机理研究》,2016/1-2018/12,主持

7. 国家自然科学基金,81501014《利用光遗传技术提高神经干细胞存活及分化率促进脑缺血康复的实验研究》,2016/1-2018/12

8. 广东省自然科学基金自由申请项目,S2013010014905,《PM2.5暴露激活IL-6信号通路诱发AS斑块不稳定性的探讨》,2013/10-2015/10,主持

9. 广东省科技计划项目,2011B031800250,《小檗碱诱导肿瘤细胞凋亡和抑制肿瘤细胞增殖的分子机制》,2012/01-2013/12,主持

10. 广东省自然科学基金博士启动项目,9451018201003601,《HIF介导急性缺血性心血管疾病作用机制的研究》,2009/10-2012/10,主持。


发表文章(部分)

1. Hongjiao Yu#1, Yingnan Lin#1, Yue Zhong#1, Xiaolan Guo1, Yuyin Lin1, Siqi Yang1, Jinglin Liu1, Xinran Xie1, Yaowei Sun1, Dong Wang2, Jianwei Dai*. Impaired AT2 to AT1 Cell Transition in PM2.5-induced Mouse model of Chronic Obstructive Pulmonary Disease, Respiratory Research, 2022

2. Xiaolan Guo#, Yuyin Lin#, Yingnan Lin, Yue Zhong, Hongjiao Yu, Yibin Huang, Jingwen Yang, Y ing Cai, FengDong Liu, Yuanyuan Li, Qian-Qian Zhang, Jianwei Dai*. PM2.5 induces pulmonary microv ascular injury in COPD via METTL16-mediated m6A modification, Environmental Pollution, 2022, 11915.

3. Junchen Li#, Lixun Huang#, Zinan He, Minggui Chen, Yi Ding, Yuying Yao, Youfa Duan, Zixuan Li, Cuiling Qi, Lingyun Zheng, Jiangchao Li, Rongxin Zhang, Xiaoming Li, Jianwei Dai*, Lijing Wang*, Qian Qian Zhang*. Andrographolide Suppresses the Growth and Metastasis of Luminal-Like Breast Cancer by Inhibiting the NF-κB/miR-21-5p/PDCD4 Signaling Pathway, Frontiers in Cell and Developmental Biology. 2021, 9(643525) doi:10.3389/FCELL.2021.643525.

4. Shiwen Wang#, Yuyin Lin#, Yue Zhong#, Maozhou Zhao, Wei Yao, Xiaohui Ren, Qin Wang, Xiaolan Guo*, QianQian Zhang*, Jianwei Dai*. The long noncoding RNA HCG18 participates in PM2.5-mediated vascular endothelial barrier dysfunction. Aging. 2020 12(23): 23960-23973.

5. Jianwei Dai*, Wensheng Chen, Yuyin Lin, Shiwen Wang, Xiaolan Guo, Qian-Qian Zhang. Exposure to Concentrated Ambient Fine Particulate Matter Induces Vascular Endothelial Dysfunction via miR-21. International Journal of Biological Sciences. International Journal of Biological Sciences. 2017 13(7): 868-877.

6. Jianwei Dai, Yuyin Lin, Youfa Duan, Zixuan Li, Dalei Zhou, Wensheng Chen, Lijing Wang and Qian-Qian Zhang. Andrographolide inhibits angiogenesis by inhibiting the miR-21-5p/TIMP3 signaling pathway. International Journal of Biological Sciences. 2017 13(5): 660-668.

7. Jianwei Dai*, Canxing Sun, Zhuo Yao, Wensheng Chen, Lihong Yu, Minhui Long. Exposure to concentrated ambient fine particulate matter disrupts vascular endothelial cell barrier function via the IL-6/HIF-1α signaling pathway. FEBS Open Bio. 2016 6(7):720-728.

8. Dai Jianwei, Zhang Qianqian, Zhang Yongliang*, Liu Songcai, Zhang Mingjun, Ren Xiaohui, Hao Linlin, and Jiang Qingyan. The Combination of a Synthetic Promoter and a CMV Promoter Improves Foreign Gene Expression Efficiency in Myocytes. Journal of Biotechnology. 2012 158 (3): 91-96. 

9. DAI Jian-wei, Yong-liang Zhang*, Song-cai Liu, Qianqian Zhang, Xiao-hui Ren, Lin-lin Hao, and Qing-yan Jiang. Simultaneous expression of Growth Hormone Releasing Hormone (GHRH) and Hepatitis B Surface Antigen/Somatostatin (HBsAg/SS) fusion genes in a construct in the skeletal muscle enhances rabbit weight gain. Animal Biotechnology. 2008 19(2): 104-16

10. Wenjing Huang, Yanyan Yan, Yun Liu, Minting Lin, Jinxiang Ma, Wei Zhang, Jianwei Dai, Jiajun Li, Qiaoru Guo, Hubiao Chen, Bolat Makabel, Hong Liu, Chaoyue Su, Hong Bi, Jianye Zhang. Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin α2β1. Signal transduction and targeted therapy. 2020 5 (1): 39.

11. Jian Chen, Zijun Zhou, Yuying Yao, Jianwei Dai, Dalei Zhou, Lijing Wang, Qianqian Zhang. Dipalmitoylphosphatidic acid inhibits breast cancer growth by suppressing angiogenesis via inhibition of the CUX1/FGF1/HGF signalling pathway. Journal of cellular and molecular medicine. 2018 22 (10): 4760-4770.

12. Xiaohui Ren, Songcai Liu, Jianwei Dai, Feng Hou, Liguang Zhou, Tiegang Lv, Yupeng Liu, Qianqian Zhang, Qingyan Jiang, Yongliang Zhang. Poly(d,l-lactide-co-glycolide) microsphere-mediated expression of growth hormone-releasing hormone in skeletal muscle of pregnant pigs enhances offspring weight gain. Livestock Science, 2011 1-3(137):124-129.

13. Linlin Hao, Mingtang Li,Jianwei Dai,Qiong Wu,Yupeng Liu,Songcai Liu,Yongliang Zhang. Reduced somatostatin in hypothalamus of young male mouse increases local but not circulatory GH. Neurochem Res. 2010 35(1):143-51.

14. Songcai LiuJianwei DaiXiaohui RenLinlin HaoYongliang Zhang. Ectopic co-expression of growth hormone releasing hormone and pituitary adenylate activating peptide in skeletal muscle enhance animal growth. Progress in Biochemistry and Biophysics. 2009 36(6) : 761-769.

15. 孙伟,胡晓东,胡耀豪,张国华,郭子雍,林菊英,黄金婷,蔡晓銮,戴建威,王新明,张小曳,毕新慧,钟南山,大气环境对SARS-COV2传播的影响研究进展,科学通报,2022

16. 郭晓兰,赵茂州,林玉茵,陈文生,王诗雯,戴建威*,穿心莲内酯抑制肿瘤细胞分泌物诱导的血管新生, 中南大学学报(医学版), 43卷,第8期,821-8252018

17. 林玉茵,陈文生,戴建威*.人生长激素释放激素受体剪接变异体1型对人肝癌细胞HepG2增殖的影响,吉林大学学报(医学版),43卷,第3期, 474-4782017

18. 郭晓兰,谭茵,陈文生,林玉茵,戴建威*GHRHR-SV1抗体的制备及其蛋白在黑色素瘤细胞中的表达,吉林大学学报(医学版),42卷,第6期,1237-1242页,2016

19. 陈文生,孙灿兴,戴建威*.番茄红素解除PM2.5暴露内皮细胞的氧化损伤,中国老年学杂志,第35卷,第15期,4150-4152页,2015

20. 戴建威,章倩倩,刘松财,张明军,张永亮*.慢病毒载体介导GHRH基因在小鼠肌肉组织表达及对动物生长影响,中国生物工程学报,第31卷,第7期,8-14页,2011

21. 戴建威,徐东刚,龙民慧*Sak衍生体对高血脂大鼠血小板功能的影响及其作用机制,吉林大学学报医学版,第36卷,第3期,461-464页,2010