陈琳
编辑:生科院     发布时间:2019-04-15

陈琳, 博士, 广州医科大学南山学者骨干人才特聘教授博士毕业于中国科学院生物物理研究所,之后加入药企从事细胞治疗相关研发工作,

2018年加入广州医科大学生科院。发表多篇第一作者文章,包括Journal of Hepatology, Cancer Research, American Journal of Pathology

合计影响因子大于25分,有丰富的肿瘤免疫和细胞治疗领域研究经验同时具备临床细胞治疗产品开发经验

陈琳课题组从事最前沿的抗肿瘤细胞免疫治疗研究,科研经费充足,科研条件优越,欢迎有意向进行转化医学的同学报考。

联系方式:chenlin@gzhmu.edu.cn。

 

过往研究经历:

  1. T细胞肿瘤免疫治疗研究:

  • T细胞肿瘤免疫治疗靶点的发现

  • TCR-T用于治疗肿瘤的体内药效学研究及安全性评价

 2. 肿瘤微环境研究:

  • S100A4阳性巨噬细胞在早期肝癌及肝纤维化中的作用

  • Tie2阳性巨噬细胞在肿瘤化疗后复发中的作用

 

Publications:

-Li Q, Dai C, Xue R, Wang P, Chen L, Han Y, Erben U, Qin Z: S100A4 protects myeloid-derived suppressor cells from intrinsic apoptosis via TLR4-ERK1/2 signaling. Frontiers in Immunology 2018;9:1-14.

-Chen L, Li J, Wang F, Dai C, Wu F, Liu X, Li T, Glauben R, Zhang Y, Nie G, He Y, Qin Z: Tie2 expression on macrophages is required for blood vessel reconstruction and tumor relapse after chemotherapy. Cancer Research 2016;76:6828-6838.

-Chen L, Li J, Zhang J, Dai C, Liu X, Wang J, Gao Z, Guo H, Wang R, Lu S, Wang F, Zhang H, Chen H, Fan X, Wang S, Qin Z: S100A4 promotes liver fibrosis via activation of hepatic stellate cells. Journal of Hepatology 2015;62:156-164.

-Sun L, Sun C, Liang Z, Li H, Chen L, Luo H, Zhang H, Ding P, Sun X, Qin Z, Zhao Y: FSP1+fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells. Scientific Reports 2015;5:1-16.

-Zhang J, Chen L, Liu X, Kammertoens T, Blankenstein T, Qin Z: Fibroblast-specific protein 1/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens. Cancer Research 2013;73:2770-2781.

-Li J, Chen L, Qin Z: Multifaceted tumor stromal fibroblasts. Cancer Microenvironment 2012;5:187-193.

-Zhang J*, Chen L*, Xiao M, Wang C, Qin Z: FSP1+fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation. American Journal of Pathology 2011;178:382-390.

-Li Z, Chen L, Qin Z: Paradoxical Roles of IL-4 in Tumor Immunity The paradox of IL-4 in tumor immunity. Cellular & Molecular Immunology 2009;2.

 

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