项 鸽：男，中共党员

办公电话：020-83079003，email: xianggeyun@163.com

广州医科大学生命科学学院，副教授（医学遗传学与细胞生物学教研室），硕士生导师。

教育经历

2012.09 - 2017.07  中国科学院大学  生物化学与分子生物学专业  博士

2009.09 - 2012.06  华南农业大学   生物化学与分子生物学专业  硕士

2005.09 - 2009.07  中南民族大学   生物工程专业        学士

工作经历

2017年10月-至今，广州医科大学，副教授

教学经历及成果

教授本科生课程《医学细胞生物学》、《医学细胞生物学（留学生）》、《细胞生物学》、《医学遗传学》、《医学遗传学（留学生）》、《普通生物学》、《细胞生物学技术》、《医学生态学》、《分子生物学》、《发酵工程》等；硕士研究生课程《分子生物学实验理论与技术》、《发育生物学与肿瘤演化》；博士研究生课程《分子遗传学》。

发表教改论文：

1.项鸽，李佩琼，陈子馨，洪怡玲，董姗姗；地中海贫血串联模式在医学遗传学教学的初探；基础医学教育；2025，27（1）：22-27。

2.项鸽，董姗姗，洪怡玲，陈子馨，梁嘉雯，莫洁莹，任娇艳，姚茂金；发育生物学与肿瘤演化课程跨学科教学实践；基础医学教育；2025，27（6）：495-500。

3.董姗姗，刘清南，李佩琼，项鸽；精准医学时代下临床药学专业特异化，医学遗传学课程教学模式构建；问答与导学；2024，7：206-208。

教学成果

1.2025年广东省大学生生物化学实验技能大赛，三等奖，2025，指导教师/第一

2.第十届全国大学生生命科学竞赛（科学探究类），广东省三等奖，2025，指导教师/第二。

研究方向：

1.细胞器重塑与干细胞命运调控

2.肿瘤发生、发展的致病机理

主持项目

1.国家自然科学基金面上项目（主持），合同经费58万；2022.1 -2025.12

2.国家自然科学基金青年基金（主持），合同经费25万；2019.1-2021.12

荣誉奖励

1.广东省科学技术奖自然科学一等奖（2020年，第三完成人），线粒体信号调控细胞命运研究，广东省人民政府。

2.中国科学院院长优秀奖（2017年），中国科学院大学。

3.第一届全国博士后创新创业大赛优胜奖（2021年，第三完成人），第一届全国博士后创新创业大赛组委会。

4.广东省精准医学科学技术奖一等奖（2023年，第四完成人），广东省精准医学应用学会。

发表文章

1.Zhongfu Ying^#, Ge Xiang ^#, Lingjun Zheng, Haite Tang, Lifan Duan, Xiaobing Lin, Qiuge Zhao, Keshi Chen, Yi Wu, Guangsuo Xing, Yiwang Lv, Linpeng Li, Liang Yang, Feixiang Bao, Qi Long, Yanshuang Zhou, Xueying He, Yaofeng Wang, Minghui Gao, Duanqing Pei, Wai-Yee Chan and Xingguo Liu*. (2018). Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming. Cell Metabolism 28(6):935-945 e935 (# Co-first author, IF=30.9)

2.Ge Xiang, Liang Yang, Qi Long, Keshi Chen, Haite Tang, Yi Wu., Zihuang Liu, Yanshuang Zhou, Juntao Qi, Lingjun Zheng, Wenbo Liu, Zhongfu Ying, Weimin Fan, Hongyan Shi, Hongmei Li, Xiaobing Lin, Mi Gao, Jinglei Liu, Feixiang Bao, Linpeng Li, Lifan Duan, Min Li and Xingguo Liu*. (2017). BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Autophagy. 13, 1543-1555. (IF=14.3)

3.Ge Xiang^#, Zihuang Liu^#, Zebin Yuan^#, Zhongfu Ying^#, Yingzhe Ding^#, Dongtong Lin, Haihao Qin, Shanshan Dong, Shihe Zhou, Hao Yuan, Wei Xie, Zhihong Zheng, Yongqiang Chen, Linpeng Li, Qi Long, Liang Yang, Yi Wu, Keshi Chen, Feixiang Bao, Yile Huang, Wei Li, Junwei Wang, Yang Liu, Dajiang Qin, and Xingguo Liu*.(2025). Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction. Stem Cell Reports 20(5):102474. (IF=5.1)

4.Zhongfu Ying, Keshi Chen, Lingjun Zheng, Yi Wu, Linpeng Li, Rui Wang, Qi Long, Liang Yang, Jingyi Guo, Deyang Yao, Yong Li, Feixiang Bao, Ge Xiang, Jinglei Liu, Qiaoying Huang, Zhiming Wu, Andrew Paul Hutchins, Duanqing Pei and Xingguo Liu*. (2016). Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming. Cell Metabolism 23(1):220-226. (IF=30.9)

5.Zhongfu Ying^#, Yanmin Xin^#, Zihuang Liu^#, Tianxin Tan, Yile Huang, Yingzhe Ding, Xuejun Hong, Qiuzhi Li, Chong Li, Jingyi Guo, Gaoshen Liu, Qi Meng, Shihe Zhou, Wenxin Li, Yao Yao, Ge Xiang, Linpeng Li, Yi Wu, Yang Liu, Miaohui Mu, Zifeng Ruan, Wenxi Liang, Junwei Wang, Yaofeng Wang, Baojian Liao, Yang Liu, Wuming Wang, Gang Lu, Dajiang Qin, Duanqing Pei, Wai-Yee Chan &Xingguo Liu*.(2025). The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming. Nature Metabolism 7, 940–951. (IF=20.8)

6.Jingyi Guo, Lifan Duan, Xueying He, Shengbiao Li, Yi Wu, Ge Xiang, Feixiang Bao, Liang Yang, Hongyan Shi, Mi Gao, Lingjun Zheng, Huili Hu, Xingguo Liu * (2021). A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome. Advanced Science 8(10): 2004680. ( IF=14.1)

7.Feixiang Bao, Lingyan Zhou, Rui Zhou, Qiaoying Huang, Junguo Chen, Sheng Zeng, Yi Wu, Liang Yang, Shufang Qian, Mengfei Wang, Xueying He, Shan Liang, Juntao Qi, Ge Xiang, Qi Long, Jingyi Guo, Zhongfu Ying, Yanshuang Zhou, Qiuge Zhao, Jiwei Zhang, Di Zhang, Wei Sun, Mi Gao, Hao Wu, Yifan Zhao, Jinfu Nie, Min Li, Quan Chen, Jiekai Chen, Xiao Zhang, Guangjin Pan, Hong Zhang, Mingtao Li, Mei Tian, Xingguo Liu *.（2022）.Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances 8(15):eabk2376. (IF=12.5)

8.Yanshuang Zhou ^#, Qi Long ^#, Hao Wu, Wei Li, Juntao Qi, Yi Wu, Ge Xiang, Haite Tang, Liang Yang, Keshi Chen, Linpeng Li, Feixiang Bao, Heying Li, Yaofeng Wang, Min Li, Xingguo Liu*. (2020). Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy 16(3):562-574. (IF=14.3)

9.Qi Long ^#, Yanshuang Zhou ^#, Hao Wu ^#, Shiwei Du, Mingli Hu, Juntao Qi, Wei Li, Jingyi Guo, Yi Wu, Liang Yang, Ge Xiang, Liang Wang, Shouhua Ye, Jiayuan Wen, Heng Mao, Junwei Wang, Hui Zhao, Wai-Yee Chan, Jinsong Liu, Yonglong Chen, Pilong Li and Xingguo Liu*. (2021). Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation. Nature Structural & Molecular Biology 28(11):900-908 (IF= 10.1)

10、Feixiang Bao, Hongyan Shi, Mi Gao, Liang Yang, Lingyan Zhou, Qiuge Zhao, Yi Wu, Keshi Chen, Ge Xiang, Qi Long, Jingyi Guo, Jian Zhang and Xingguo Liu*. (2018). Polybrene induces neural degeneration by bidirectional Ca(2+) influx-dependent mitochondrial and ER-mitochondrial dynamics. Cell Death & Disease 9(10):966.(IF=9.6)

11.Linpeng Li ^#, Keshi Chen ^#, Yi Wu ^#, Ge Xiang, Xingguo Liu *. (2021). Epigenome-Metabolome-Epigenome signaling cascade in cell biological processes. Journal of Genetics and Genomics S1673-8527(21)00321-0. (IF=7.1)

12.Liang Yang ^#, Haite Tang ^#, Xiaobing Lin, Yi Wu, Sheng Zeng, Yongzhang Pan, Yukun Li, Ge Xiang, Yi-Fang Lin, Shi-Mei Zhuang, Zhiyin Song, Yiguo Jiang and Xingguo Liu*. (2020). OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion. Frontiers in Cell and Developmental Biology 8:180. (IF=4.3)

13.Wenbo Liu, Qi Long, Keshi Chen, Shengbiao Li, Ge Xiang, Shen Chen, Xiyin Liu, Yuxing Li, Liang Yang, Delu Dong, Cheng Jiang, Zhenhua Feng, Dajiang Qin, Xingguo Liu*. (2013). Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation. Biochemical and Biophysical Research Communications 431, 767-771.(IF=2.2)

14.Zhongfu Ying ^#, Zihuang Liu ^#, Ge Xiang, Yanmin Xin, Junwei Wang, Xingguo Liu *. (2021). Protocols for analysis of mitochondrial permeability transition pore opening in mouse somatic cell reprogramming. STAR Protocols,2(2):100568. (IF=1.3)

15.WU Yi (邬毅)，CHEN KeShi (陈可实)，XIANG Ge (项鸽)，YING ZhongFu （应仲富）& LIU XingGuo （刘兴国）*. (2020). Organelle Remodeling during the Acquistion and Loss of Pluripotency. Science Foundation in China 28, NO.1（国家自然科学基金委员会期刊）

社会任职/学术任职

1.中国生物物理学会代谢生物学分会，青年副秘书长

2.广东省生物化学与分子生物学学会，常务理事