Miguel Angel Esteban, MD, PhD
Citizenship: Spanish; date of birth: 9th February 1970
Current address:
Key Laboratory of Regenerative Biology
South China Institute for Stem Cell Biology and Regenerative Medicine
Guangzhou Institutes of Biomedicine and Health (Chinese Academy of Sciences),
Guangzhou International Business Incubator, Block D 7th floor, Science Park, Guangzhou
510530, China
Email: esteban@gibh.org
Current post:
Principal Investigator/Professor
Education:
1988-1994 Bachelor in Medicine and Surgery
University of Navarra, Pamplona (Spain)
Postgraduate degree in Clinical Immunology, resident doctor
Department of Immunology, Hospital de la Princesa, Madrid (Spain)
1999-2003 Ph.D. in Biochemistry and Molecular Biology
Department of Biochemistry, University Autonoma de Madrid (Spain)
Supervisor: Manuel Ortiz de Landázuri
Viva in September 2004
Title of the Thesis: ‘Role of the von Hippel-Lindau
tumor suppressor gene in the control of extracellular matrix assembly and epithelial characteristics’
Cum laude
Research experience:
1992-1993 Research assistant (internship) in the Department of Pathology (University of Navarra)
1992-1993 Research assistant (internship) in the Department of Microbiology
(University of Navarra)
1999-2004 PhD student (University Autonoma de Madrid)
2004-2007 Postdoctoral research associate
Renal research laboratory, department of Medicine,
Imperial College London, group leader: Professor Patrick H. Maxwell
2008-onwards Principal Investigator, Guangzhou Institutes of Biomedicine and Health
(China)
Grants, awards and active memberships:
Predoctoral fellowship FPI award (1999-2001); organization: Comunidad Autonoma Madrid
Predoctoral fellowship BEFI award (2001-2004); organization: Instituto Salud Carlos III
Short travelling research award (June-December 2003); organization: Instituto Salud Carlos III; place: Renal Research laboratory at Imperial College London
International travelling research award (2004-2006); organization: Wellcome Trust
Title of the project: ‘Enzyme-substrate interactions underlying the hydroxylation of Hypoxia-Inducible Factor by oxygen dependent-dioxygenases’
Cancer Research UK project grant (2004-2007) (C7899/A5165)
Title: ‘Role of the von Hippel-Lindau tumour suppressor in regulating intercellular adhesion’
Principal investigator: Patrick H. Maxwell, co-investigator: Esteban MA
Three years Cancer Research UK project associated grant (2007-2010) (C7899/A7797)
Title: ‘Role of Hypoxia-Inducible Factor in controlling epithelial-to-mesenchymal transitions’
Principal investigator: Patrick H. Maxwell, co-investigator: Esteban MA
I remained as co-investigator after leaving the UK in December 2007
Selected by the British Council to take part in the first ICYS (International Network for Young Scientists) between the UK and China, held in Guangzhou in November 2006
Chinese Academy of Sciences project grant (KSCX2-YW-R-244) 10/2009-12/2010
Title: Role of TGFb pathway in somatic cell reprogramming
Principal investigator
Fund: 0.30million
National Natural Science Foundation of China grant (31071309) 01/2011-12/2013
Title: Role of hypoxia-inducible factor (HIF) in somatic cell reprogramming
Principal investigator
Fund: 0.35million
Ministry of Science and Technology of China National 973 program grant (2011CB965200)
01/2011-08/ 2015
Title: Characterization of induced pluripotent stem cells generated from different tissues and diseases
Lead scientist
Fund: 24.95million
First foreign-born leading scientist of Chinese 973 program
Strategic Priority Research Program" of the Chinese Academy of Sciences (XDA01020106)
01/2011-12/ 2015
Title: New technology of directional differentiation
Principal investigator
Bureau of Science and Technology of Guangzhou Municipality grant(2012J5100040)
08/2012-07/2015
Title: iPS cell-based therapies for treating liver disease
Principal investigator
Fund: 4 million
Q-CAS Biotechnology Fund grant (GJHZ1242)
10/2012-09/2015
Title: A model for understanding and treating amyotrophic lateral sclerosis using induced pluripotent stem cells
Principal investigator
Fund: 0.30 million
International Cooperation and Exchanges, NSFC-RGC grant(81261160506)
01/2013-12/2016
Title: Targeted gene correction and disease modeling using Wilson’s disease induced pluripotent stem cells
Principal investigator
Fund: 0.8million
International Cooperation and Exchanges, NSFC-MRC grant (81261130317)
10/2012-09/2013
Developing stem cell-related therapies for the treatment of inherited and acquired liver disease
Fund: 0.30million
NSFC general program (31371513)
01/2014-12/2017
Title: The role of class IIa HDACs in somatic cell reprogramming and embryonic stem cells
Principal investigator
Fund: 0.8million
Guangdong Province Science and Technology program(2013B050800010)
08/2014-2016/6
Title: Drug screening and tranplantation using a cell platform derived from human iPSCs study on hyerlipidmia disease
Principal investigator
Fund: 0.45 million
Guangdong Province NSFC Team grant
10/2014-10/2019
Title:Establish a neuron platfrom from Parkinson's disease patient and conduct study on pathogenesis and disease treatment
Principal investigator
Fund: 3 million
2011,2012 State Administration of foreign Experts Affairs, China, High foreign expert program 高端外籍专家
2011 Guangzhou friendship award 羊城友谊奖
2012 Zhu Li Yue Hua Award for Excellent teacher 朱李月华优秀教师奖
Have educated 12 PhD. graduates, 10 Master graduates, have 20 students in the lab now including 5 foreign students
Journal of Biological chemistry Editorial Board member since 2012
Executive Editor of Cell Regeneration
Areas of expertise:
Immunology (special emphasis on inflammation), Cancer Biology (in particular related to hypoxia and oxygen sensing), genetic syndromes, Stem Cell Biology (in particular related to induced pluripotent stem cells and embryonic stem cells), Link-RNA
Publications: * Corresponding author
1- Muñoz C, Castellanos MC, Alfranca A, Vara A, Esteban MA, Redondo JM, de Landázuri MO.Transcriptional up-regulation of intracellular adhesion molecule-1 in human endotelial cells by the antioxidant pyrrodiline dithiocarbamate involves the activation of activating protein-1. Journal of Immunology 1996. 157: 3587-97.
2- Esteban MA, Avila P, Alvarez-Tejado M, Gutiérrez MD, García-Pardo A, Sánchez-Madrid F, Landázuri MO. Role of the von Hippel-Lindau Tumor Suppressor Gene in the Formation of ß1-Integrin Fibrillar Adhesions. Cancer Research 2002. 62: 2929-36.
3- Cuevas Y, Hernández-Alcoceba R, Aragones J, Naranjo-Suárez S, Castellanos MC, Esteban MA, Martín-Puig S, Landazuri MO, del Peso L. Specific Oncolytic Effect of a New Hypoxia-Inducible Factor-Dependent Replicative Adenovirus on von Hippel-Lindau-Defective Renal Cell Carcinomas. Cancer Research 2003. 63: 6877-84.
4- Esteban MA, Mandriota S, Maxwell PH. The von Hippel-Lindau Protein: a key player in oxygen homeostasis and matrix assembly. International Congress Series 2004. 1262: 450-3.
5- Esteban MA, Maxwell PH. Manipulation of oxygen tensions for in vitro cell culture using a hypoxic workstation. Expert Review in Proteomics 2005. 2: 307-14.
6- Esteban MA, Maxwell PH. HIF, a missing link between metabolism and cancer. Nature Medicine 2005. 10: 1047-48. (News and Views)
7- Esteban MA, Tran MG, Harten SK, Hill P, Castellanos MC, Chandra A, Raval R, O'brien TS, Maxwell PH. Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer Research 2006. 66: 3567-675.
8- Calzada MJ, Esteban MA, Feijoo-Cuaresma M, Castellanos MC, Naranjo-Suárez S, Temes E, Méndez F, Yánez-Mo M, Ohh M, Landázuri MO.The VHL tumor suppressor gene regulates the assembly of intercellular junctions through HIF independent mechanisms. Cancer Research 2006. 66: 1553-60.
9- Esteban MA, Harten SK, Tran MG, Maxwell PH. Formation of primary cilia in the kidney epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. Journal of the American Society of Nephrology 2006. 17: 1801-06.
10- Kiriakidis S, Esteban MA, Maxwell PH.Genetic insights into the hypoxia-inducible factor (HIF) pathway. Advanced Enzyme Regulation. 2007. 47: 288-306.
11- Boutet A, Esteban MA, Maxwell PH, Nieto MA. Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis? Cell Cycle 2007. 6: 638-42.
12- Feijóo-Cuaresma M, Méndez F, Maqueda A, Esteban MA, Naranjo-Suarez S, Castellanos MC, del Cerro MH, Vazquez SN, García-Pardo A, Landázuri MO, Calzada MJ. Inadequate activation of the GTPase RhoA contributes to the lack of fibronectin matrix assembly in von Hippel-Lindau defective renal cancer cells. Journal of Biological Chemistry 2008. 283: 24982-90.
13- Zhang X, Zhang J, Wang T, Esteban MA, Pei D. Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. Journal of Biological Chemistry 2008. 283: 35825-33.
14- Qin D, Gan Y, Shao K, Wang H, Li W, Wang T, He W, Xu J, Zhang Y, Kou Z, Zeng L, Sheng G, Esteban MA, Gao S, Pei D. Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factors. Journal of Biological Chemistry 2008. 283: 33730-5.
15- Esteban MA, Gang Y, Qin D, Pei D. Induced Pluripotent Stem Cell Technology: Promises and Challenges. Chinese Science Bulletin 2009. 1: 2-8. Cover story
16- Sarah K. Harten, Deepa Shukla, Ravi Barod, Alexander Hergovich, Maria Balda, Karl Matter, and Esteban MA* and Patrick H. Maxwell. Regulation of Renal Epithelial Tight Junctions by the von Hippel-Lindau Tumor Suppressor Gene Involves Occludin and Claudin 1 and Is Independent of E-Cadherin. Molecular Biology of the Cell 2009. 20: 1089-1101.
17- Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ. Deletion of the VHL tumor suppressor gene in pancreatic beta cells impairs glucose homeostasis in mice. Journal of Clinical Investigation 2009. 119: 125-35.
18- Harten SK, Esteban MA, Maxwell PH. Identification of novel VHL regulated genes by transcriptomic analysis of RCC10 renal carcinoma cells. Advanced Enzyme Regulation 2009. 49: 43-52.
19- Esteban MA, Xu J, Yang J, Peng M, Qin D, Li W, Jiang Z, Chen J, Deng K, Zhong M, Cai J, Lai L, Pei D. Generation of induced pluripotent stem cell lines from Tibetan miniature pig. Journal of Biological Chemistry 2009. 284: 17634-40.
20- Esteban MA, Wang T, Qin B, Yang J, Qin D, Cai J, Li W, Weng Z, Chen J, Ni S, Chen K, Li Y, Liu X, Xu J, Zhang S, Li F, He W, Labuda K, Song Y, Peterbauer A, Wolbank S, Redl H, Zhong M, Cai D, Zeng L, Pei D. Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells. Cell Stem Cell 2010. 6(1): 71-79. Cover story
Preview of this article in the same issue: Powering Reprogramming with Vitamin C, by Hongkui Deng et al.
International press coverage (two links are included):
http://www.scientificamerican.com/article.cfm?id=induced-pluripotent-stem-cells-ips-vitamin-c-antioxidant (Scientific American: Vitamin C boosts the generation of pluripotent stem cells; the commentary also appeared in print in the March issue).
http://biotecnologia.diariomedico.com/2009/12/28/area-scientifica/especialidades/biotecnologia/investigacion/la-vitamina-c-potencia-la-generacion-de-celulas-ips (Diario Medico.com: La vitamina C potencia la generación de células iPS)
Most read article of the month in Cell Stem Cell after 4 days of publication online
21- Li R, Liang J, Ni S, Zhou T, Qing X, Li H, He W, Chen J, Li F, Zhuang Q, Qin B, Xu J, Li W, Yang J, Gan Y, Qin D, Feng S, Song H, Yang D, Zhang B, Zeng L, Lai L, Esteban MA*, Pei D. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 2010. 7 (1): 51-63.
Among top ten scientific articles of the year in China
22- Esteban MA, Peng M, Deli Z, Cai J, Yang J, Xu J, Lai L, Pei D.Porcine induced pluripotent stem cells may bridge the gap between mouse and human iPS. IUBMB Life 2010. 62(4): 277-82.
23- Chen J, Liu J, Han Q, Qin D, Xu J, Chen Y, Yang J, Song H, Yang D, Peng M, He W, Li R, Wang H, Gan Y, Ding K, Zeng L, Lai L, Esteban MA, Pei D. Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells. Journal of Biological Chemistry 2010. 285(40): 31066-72.
24- Xu J, Li H, Wang B, Xu Y, Yang J, Zhang X, Harten SK, Shukla D, Maxwell PH, Pei D, Esteban MA*. VHL Inactivation Induces HEF1 and Aurora Kinase A. Journal of the American Society of Nephrology 2010. 21(12): 2041-2046.
25- Pei D, Xu J, Zhuang Q, Tse HF, Esteban MA*. Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Biology. Advances in Biochemical Engineering/ Biotechnology 2010. 123: 127-141.
26- Yang J, Cai J, Zhang Y, Wang X, Li W, Xu J, Li F, Guo X, Deng K, Zhong M, Chen Y, Lai L, Pei D*, Esteban MA*. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry 2010. 285(51): 40303-11.
27- Cai J, Li W, Su H, Qin D, Yang J, Zhu F, Xu J, He W, Guo X, Labuda K, Peterbauer A, Wolbank S, Zhong M, Li Z, Wu W, So KF, Redl H, Zeng L, Esteban MA*, Pei D*. Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells. Journal of Biological Chemistry 2010. 285(15):11227-34.
28- Lian Q, Chow Y, Esteban MA, Pei D, Tse HF.Future perspective of induced pluripotent stem cells for diagnosis, drug screening and treatment of human diseases. Thromb Haemost 2010. 104(1):39-44.
29- Ho JC, Zhou T, Lai WH, Huang Y, Chan YC, Li X, Wong NL, Li Y, Au KW, Guo D, Xu J, Siu CW, Pei D, Tse HF*, Esteban MA*. Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C. AGING 2011. 22(7): 1221-8.
30- Liao B, Bao X, Liu L, Feng S, Zovoilis A, Liu W, Xue Y, Cai J, Guo X, Qin B, Zhang R, Wu J, Lai L, Teng M, Niu L, Zhang B*, Esteban MA*, Pei D.Microrna cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. Journal of Biological Chemistry 2011. 286(19): 17359-64.
31- Zhou T, Benda C, Dunzinger S, Huang Y, Ho JC, Yang J, Wang Y, Zhang Y, Zhuang Q, Li Y, Bao X, Tse HF, Grillari J, Grillari-Voglauer R*, Pei D, Esteban MA*. Generation of human induced pluripotent stem cells from urine. Journal of the American Society of Nephrology 2011. 22(7): 1221-8.
32- Khan MN, Bhattacharyya T, Andrikopoulos P, Esteban MA, Barod R, Connor T, Ashcroft M, Maxwell PH, Kiriakidis S. Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis. British Journal of Cancer 2011. 104(7): 1151-9.
33- Zhang S, Chen S, Li W, Guo X, Zhao P, Xu J, Chen Y, Pan Q, Liu X, Zychlinski D, Lu H, Tortorella MD, Schambach A, Wang Y, Pei D, Esteban MA*. Rescue of ATP7B function in hepatocyte-like cells from Wilson’s disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin. Human molecular genetics 2011. 20(16): 3176-87.
34-J Xu, B Wang, Y Xu, L Sun, W Tian, D Shukla, R Barod, J Grillari, R Grillari-Voglauer, PH Maxwell and Esteban MA*. Epigenetic regulation of HIF-1a in renal cancer cells involves
HIF-1a/2a binding to a reverse hypoxia-response element. Oncogene 2011.31(8):1065-72.
35- Harten SK, Esteban MA, Shukla D, Ashcroft M, Maxwell PH. Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells. Molecular Cancer 2011. 26;10:89.
36- Wang T, Chen K, Zeng X, Yang J, Wu Y, Shi X, Qin B, Zeng L, Esteban MA, Pan G, Pei D. Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin C Dependent Manner. Cell Stem Cell 2011. 9(6): 575-587.
37- Li W, Wang X, Fan W, Zhao P, Chan YC, Chen S, Zhang S, Guo X, Zhang Y, Li Y, Cai J, Qin D, Li X, Yang J, Peng T, Zychlinski D, Hoffmann D, Zhang R, Deng K, Ng KM, Menten B, Zhong M, Wu J, Li Z, Chen Y, Schambach A, Tse HF, Pei D*, Esteban MA*. Modeling Abnormal Early Development with Induced Pluripotent Stem Cells from Aneuploid Syndromes. Human molecular genetics 2012. 21(1): 32-35.
38- Yao Y, Nashun B, Zhou T, Qin L, Qin L, Zhao S, Xu J, Esteban MA, Chen X.Generation of CD34 Cells from CCR5-disrupted Human Embryonic and Induced Pluripotent Stem Cells. Human gene therapy 2012. 23(2):238-42.
39- Esteban MA*, Pei D*. Vitamin C improves the quality of somatic cell reprogramming. Nature Genetics 2012.44(4):36-7.
40- Zhou T, Benda C, Dunzinger S, Huang Y, Ho JC, Yang J, Wang Y, Zhang Y, Zhuang Q, Li Y, Bao X, Tse HF, Grillari J, Grillari-Voglauer R, Pei D, Esteban MA*. A protocol for generating human induced pluripotent stem cells from urine samples. Nature protocol 2012.10:2080-9
41- Esteban MA, Bao X, Zhuang Q, Qin B, Pei D. The mesenchymal-to-epithelial transition in somatic cell reprogramming. Current Opinion in Genetics & Development 2012. 22(5):423-8.
42- Benda C, Zhou T, Wang X, Tian W, Grillari J, Tse HF, Grillari-Voglauer R, Esteban MA*. Urine as a source of stem cells. Adv Biochem Engin/Biotechno 2013. 129:19-32.
43- Tian W, Cui F, Esteban MA*. E2F1 in renal cancer: Mr Hyde disguised as Dr Jekyll?Journal of Pathology 2013. 231: 143–146
44- Zhuang Q, Qing X, Ying Y, Wu H, Benda C, Lin J, Huang Z, Liu L, Xu Y, Bao X, Qin B, Pei D, Esteban MA*. Class IIa histone deacetylases and myocyte enhancer factor 2 proteins regulate the mesenchymal-to-epithelial transition of somatic cell reprogramming. Journal of Biological Chemistry 2013. 288(17) 12022-31.
45- Bao X, Zhu X, Liao B, Benda C, Zhuang Q, Pei D, Qin B, Esteban MA*. MicroRNAs in somatic cell reprogramming. Current Opinion in Cell Biology 2013. 25(2):208-14.
46- Fan N, Chen J, Shang Z, Dou H, Ji G, Zou Q, Wu L, He L, Wang F, Liu K, Liu N, Han J, Zhou Q, Pan D, Yang D, Zhao B, Ouyang Z, Liu Z, Zhao Y, Lin L, Zhong C, Wang Q, Wang S, Xu Y, Luan J, Liang Y, Yang Z, Li J, Lu C, Vajta G, Li Z, Ouyang H, Wang H, Wang Y, Yang Y, Liu Z, Wei H, Luan Z, Esteban MA, Deng H, Yang H, Pei D, Li N, Pei G, Liu L, Du Y, Xiao L, and Lai L. Piglets cloned from induced pluripotent stem cells. Cell Research 2013. 23: 162-6.
47- Tse HF, Ho JC, Choi SW, Lee YK, Butler AW, Ng KM, Siu CW, Simpson MA, Lai WH, Chan YC, Au KW, Zhang J, Lay KW, Esteban MA, Nicholls JM, Colman A, and Sham PC. Patient-specific induced pluripotent stem cells-derived cardiomyocytes recapitulate the pathogenic phenotypes due to a novel DES mutation identified by exome sequencing. Human Molecular Genetics 2013. 22(7) 1395-403.
48- Xu Y, Liu L, Laslett AL, Esteban MA *. Cell Reprogramming: into the groove. Nature Materials. 2013. 12:1082-1084. (News and Views)
49- Takebayashi S, Lei I, Ryba T, Sasaki T, Dileep V, Battaglia D, Gao X, Fang P, Fan Y, Esteban MA, Tang J, Crabtree GR, Wang Z, Gilbert DM. Murine BAF chromatin remodeling complexes are necessary to maintain and reprogram replication-timing. Epigenetics & Chromatin. 2013. 6:42
50-Fan N, Chen J, Shang Z, Dou H, Ji G, Zou Q, Wu L, He L, Wang F, Liu K, Liu N, Han J, Zhou Q, Pan D, Yang D, Zhao B, Ouyang Z, Liu Z, Zhao Y, Lin L, Zhong C, Wang Q, Wang S, Xu Y, Luan J, Liang Y, Yang Z, Li J, Lu C, Vajta G, Li Z, Ouyang H, Wang H, Wang Y, Yang Y, Liu Z, Wei H, Luan Z, Esteban MA, Deng H, Yang H, Pei D, Li N, Pei G, Liu L, Du Y, Xiao L, Lai L. Piglets cloned from induced pluripotent stem cells. Cell Research 2013. 23:162-166. IF 11.981
51- Tian W, Wang Y, Xu Y, Guo X, Wang B, Sun L, Liu L, Cui F, Zhuang Q, Bao X, Schley G, Chung TL, Laslett AL, Willam C, Qin B, Maxwell PH, Esteban MA *. Hypoxia-Inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-Induced Toxicity. Journal of Biological Chemistry 2014. 289(6): 3339-51.
52- Harreither E, Rydberg HA, Åmand HL, Jadhav V, Fliedl L, Benda C, Esteban MA, Pei D, Borth N, Grillari-Voglauer R, Hommerding O, Edenhofer F, Nordén B, Grillari J. Characterization of a novel cell penetrating peptide 1 derived from human Oct4. Cell Regeneration. 2014. 3:2
53- Ji J, Sharma V, Qi S, Guarch ME, Zhao P, Luo Z, Fan W, Wang Y, Mbabaali F, Neculai D, Esteban MA, McPherson JD, Batada NN. Antioxidant supplementation reduces genomic aberrations in human induced pluripotent stem cells. Stem Cell Reports 2014. 2(1) 44-51.
54- Wang Y, Fan N, Tian W, Cui F, Newsome PN, Frampton J, Esteban MA* and Lai L*. Generation of knockout rabbits using transcription activator-like effect or nucleases. Cell Regeneration 2014. 3:3
55- Lee YK, Ho PW, Schick R, Lau YM, Lai WH, Zhou T, Li Y, Ng KM, Ho SL, Esteban MA, Binah O, Tse HF, Siu CW. Modeling of Friedreich ataxia-related iron overloading cardiomyopathy using patient-specific-induced pluripotent stem cells. European Journal of Physiology. (epub December 11, 2013)
56- Huang J, Guo X, Fan N, Song J, Zhao B , Zhen O, Liu Z, Zhao Y, Yan Q, Yi X, Schambach A, Frampton J, Esteban MA , Yang D, Yang H and Lai L.RAG1/2 Knockout Pigs with Severe Combined Immunodeficiency. Jounal of Immunology 2014. 193(3). 1496-503.
57-Zhou X, Xin J, Fan N, Zou Q, Huang J, Ouyang Z, Zhao Y, Zhao B, Liu Z, Lai S, Yi X, Guo L, Esteban MA, Zeng Y, Yang H, Lai L.Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer. Cell Mol Life Sci. 2014 Oct 2. [Epub ahead of print] IF 5.856
58-Zhao P, Luo Z, Tian W, Yang J, Ibáñez DP, Huang Z, Tortorella MD, Esteban MA*, Fan W. Solving the puzzle of Parkinson's disease using induced pluripotent stem cells. Exp Biol Med (Maywood). 2014. 239(11):1421-32
59- Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D,Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA*. Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming. Cell Stem Cell, 2014.15.574-588. IF 22.151
60- Bao X, Wu H, Zhu X, Guo X, Hutchins A, Luo Z, Song H, Chen Y, Lai K, Yin M, Xu L, Zhou L, Chen J, Dongye Wang, Qin B, Frampton J, Tse HF, Pei D, Wang H, and Zhang B, Esteban MA*. The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. Cell Research. 2015.25(1).80-92.
61- Wang L, Zhao Y, Bao X, Zhu X, Kwok YK, Sun K, Chen X2, Huang Y, Jauch R, Esteban MA, Sun H, Wang H. LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration. Cell research, 2015, 25, 335-350.
62- Zhou X, Xin J, Fan N, Zou Q, Huang J, Ouyang Z, Zhao Y, Zhao B, Liu Z, Lai S, Yi X, Guo L, Esteban MA, Zeng Y, Yang H, Lai L. Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer. Cellular and molecular life sciences: CML