CURRICULUM VITAE
Duanqing Pei, Ph.D.
Address: Guangzhou Institute of Biomedicine and Health
Chinese Academy of Sciences Guangzhou 510530
China
Email: pei_duanqing@gibh.ac.cnPhone: (+86)-20-3229-0209Fax: (+86)-20-3229-0606
Date of birth: June 17th 1965 in Gongan, Hubei, China
Education
1980-1984 Central China Univ. of Agriculture, Wuhan, China, B.A.1985-1991 University of Pennsylvania, Philadelphia, Ph.D. Thesis: “Liver gene expression and hepatitis B virus: The characterization of the liver enriched transcriptional factor CCAAT/enhancer binding protein C/EBP”. Advisor: Chiaho Shih, Ph.D.
Postdoctoral training
1991.6 - 1995. 3 Postdoctoral Research Fellow, Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical Center, Ann Arbor, MI
Mentor: Stephen J. Weiss, M.D.
Academic Appointments
1995.4- 1996.8 Research Investigator, Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical Center, Ann Arbor, MI.
1996.9- 2002.6 Assistant Professor, Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455
1997.9-2004.9 Member, Cancer Metastasis/Cell Biology program, University of Minnesota Comprehensive Cancer Center, MN 55455
2002.6-2004.7 Associate Professor with Tenure, Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455
2002.1-2004.6 Professor and Director, Institute of Pharmacology, Tsinghua University, Beijing, China.
2003.8-2006.7 Visiting Professor, Shanghai Institute of Organic Chemistry, Shanghai, China.
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C.V. Duanqing Pei, Ph.D.January 4, 2016
2004.2-2007.1 Honorary Professor, Department of Pharmacology, University of Hong Kong, Hong Kong, China.
2004.7-2008.6 Professor and Deputy Director General, GIBH, Chinese Academy of Sciences, Guangzhou, China
2008.6- Professor and Director General, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China
Corporate Relationships
R&D system, Consultant to the MMP unit; funds to support general projects; 1999-2000
CalBiochem Corp, funds to support MMP related projects, 1997- 2001.
Chemicon International, MT5-MMP project 1999-2002.Bristol Meyer Squibb, Funds to support Leukolysin project, 2000- 2002.
Pfizer, Funds to support the aggrecanase project, 2003-2005Pfizer, consultant, 2004-2008
Patents (more than 20 patents published or issued)
Honors and awards
1981-1982 Best Student Award, Central China University of Agriculture, Wuhan, China
1985 Fellowship: China-United States Biochemistry and Molecular Biology Examination and Application Program (CUSBEA program)1994 Research Award, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI.
1997 Feltl family Award, Arthritis Foundation-MN chapter.2000 Ziegler Family Research Award, Arthritis Foundation.2002 Career Investigator Award, American Lung Association.2003 Honorary Professor, University of Hong Kong
2006 Chair, Matrix Metalloproteinases in Cancer, IUPHAR 2006.2006 Co-Chair, 9th Annual Chinese-American Frontiers of Science Symposium of the Chinese Academy of Sciences and the National Academy of Sciences of USA, Irvine, California.
2007 Co-Chair, #313 Xiangshan meeting on “stem cell biology and cloning”, Xiangshan, Beijing; Nov, 2007.
2009 Program chair, 2009 IUBMB congress, Shanghai, China; Aug 2-7.2010 Co-Organizer, Cold Spring Harbor Asia Symposia: Molecular Switches and Genome Function in Stem Cells and Developments, Sept 21-25, Suzhou, China.
2012 Co-organizer, City of Hope International Stem Cell and Cancer Symposium, Oct 4-5, 2012. Duarte, CA.
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C.V. Duanqing Pei, Ph.D.January 4, 2016
2013 Co-organizer, Nature Conferences, Nuclear Reprogramming and Cancer Genome, Oxford, UK., Sept 25-28, 2013.
2014 Co-organizer, Nature Conferences, Nuclear Reprogramming and Cancer Genome, Guangzhou., Oct31-Nov2, 2014.
2015 Founding co-chair, Gordon Research Conference on Genome Architecture in Cell fate and diseases, CUHK site, June, 2015
Grant Review Committees
Arthritis Foundation Small Grant Committee, MN chapter, 1999-2002Alzheimer’s Disease Foundation, 2001.
AHC seed grant review panel 2001, University of Minnesota.NIH, Tumor Microenvironment Study Section (TME), standing member,2004-2006
NIH, Pathobiochemistry Study Section (PBC) 2004.2.26.NIH, ZRG1, ONC M 03, 2004.4.1.
The Susan G.Koman Breast Cancer Foundation, Tumor Cell, 2004, Feb. –NIH, Molecular Mechanisms of Metastasis ZRG1 ONC-D, 2004.8.4.
In China:
Council member, the national 863 HighTech Program, 2006.10-2009.9Member, the national Medium-Long Term Science and Technology basic science program in “Reproduction and Development”. 2006-2010Member, NSFC review panel in Genetics and Development (2008-10)Member, NSFC review panel for outstanding young scientist (panel 2)Member, NSFC review panel for key projects (panel 3)
Chair, National Medium-Long Term Science and Technology basic science program in “Stem Cell”. 2011-13
Professional Activities
Member, Scientific Committee, Arthritis Foundation MN chapter, 1999-Member, American Society of Cell Biololgy, 2000- Member, American Society of Microbiology, 2000- Member, Biochemical Society, London, 2000-
Member, American Association for Cancer Research, 1997-Member, International Proteolysis Society, 1999-
Member, American Society of Biochemistry and Molecular Biology, 2003-Member, American Society of Pharm. and Experimental Therapeutics, 2003-Lifetime Member, Society of Chinese Biologists in America (SCBA).Member, International Society for Stem Cell Research (ISSCR)Member, ISSCR clinical translation committee, 2012- presentMember, ISSCR public Policy committee, 2015- present Member, ISSCR 2014 Annual Meeting program committee.
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C.V. Duanqing Pei, Ph.D.January 4, 2016
Founding Chair, 2015 Gordon Research Conference on “Genome Architecture in Cell Fate and Disease”
Planning Committee, International Summit on Human Gene Editing organized byNational Academy of Sciences, National Academy of Medicine, Royal Society ofLondon, and Chinese Academy of Sciences (Chair, David Baltimore) 2015.Member, Study Group on Human Gene Editing, National Academy of Sciencesand National Academy of Medicine (Co-chairs: Richard Hynes, Alta Charo) 2015-
2016.
Editorial Services
Regular:
The Journal of Biological Chemistry, Editorial Board, 2006.6-2011.9Biochemical Journal, Editorial Advisory Panel, 2001-2003Cell Research, Associate Editor, 2006.1.1-2010
Cell Research, Editorial Board, 2011-
Archives of Biochemistry and Biophysics, Editorial Board, 2004-Stem Cell Research and Therapy, 2009-Cell Regeneration, Editor-in-Chief, 2012-EMBO Reports, 2014-
Ad hoc
Journal of Experimental Medicine
Proceedings of National Academy of Sciences (PNAS)
Cell Stem CellNature Cell BiologyNature CELL
Nature MethodsNature GeneticsMolecular Cell
Invited Lectures (Select)
More than 300 invited lectures, among others at Gordon Research Conferences,Keystone meetings., Cold Spring Harbor meetings, ISSCR meeting., CambridgeUniversity, UK., Oxford University, UK., Karolinska Institute, Sweden., Universityof California, Irvine., University of Michigan., Mayo Clinic (Rochester, MN), MDAnderson Cancer Center (Houston, TX), Albers Einstein College of Medicine(NY), Burnham Institute (San Diego, CA), Imperial College London, and atseveral companies (e.g. Glaxo Smith Kline, Pfizer, Calbiochem)
Publications
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C.V. Duanqing Pei, Ph.D.January 4, 2016
1. Pei, D., C. Shih. 1990. Transcriptional repression and activation by cellular DNA-binding protein C/EBP. J. Virol. 64: 1517-1522.
2. Pei, D., C. Shih. 1991. An attenuator is sandwiched by two transactivation domains in the transcriptional factor C/EBP. Mol. Cell. Biol. 11: 1480-1487.
3. Pei, D., Majmudar, G., Weiss, S.J. 1994. Hydrolytic inactivation of a breast carcinoma cell- derived serpin by human stromelysin-3. J Biol. Chem; 269: 25849-25855.
4. Pei, D., Weiss, S.J. 1995. Furin-dependent Intracellular Activation of the Human Stromelysin-3 Zymogen. Nature. 375: 244-247.
5. Pei, D., Weiss, S.J., 1996. Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity. J. Biol. Chem. 271 (15): 9135-9140.
6. Pei, D., Yi, J. 1998. A High Level Mammalian Expression System Based on the Madin-Darby canine kidney (MDCK) cell line. Prot. Exp.& Puri. 13: 277-281.
7. Lei, J., Jiang, A., and Pei, D. 1998. Identification and Characterization of a New Splicing Variant of Vascular Endothelial Growth Factor: VEGF183. Biochim. Biophys. Acta 1443 (3): 400-406.
8. Pei, D. 1999. Identification and characterization of the fifth member of the membrane-type matrix metalloproteinase MT5-MMP. J. Biol. Chem. 274: 8925-8932.
9. Pei, D. 1999. CA-MMP: a matrix metalloproteinase with a novel cysteine-array, but without the classic cysteine switch. FEBS Lett. 457: 262-270.
10. Wang, X., Lei, L., Yi, J. and Pei, D. 1999. Expression, Purification and Charaterization of Recombinant Mouse MT5-MMP Protein Products. FEBS Lett. 462: 261-266.
11. Pei, D. 1999. MMP25/MT6-MMP/Leukolysin: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage, Cell Res. 9: 291-303.
12. Pei, D., Kang, T., and Qi, H. 2000. CA-MMP/MMP-23 is a Type II Transmembrane Matrix Metalloproteinase Regulated by a Single Cleavage for Both Secretion and Activation. J. Biol. Chem. 275: 33988-33997.
13. Kang, T., Yi, J., Yang, W., Wang, X., Jiang, A., and Pei, D. 2000. Functional characterization of MT3-MMP in transfected MDCK cells: progelatinase A activation and tubulogenesis in 3-D collagen lattice. FASEB J. 14:2559-2568.
14. Damjanovski, S., Amano, T., Li, Q., Pei, D., and Shi, Y.-B. 2001. Overexpression of Matrix Metalloproteinases Leads to Lethality in Transgenic Xenopus Laevis: Implications for Tissue- Dependent Functions of Matrix Metalloproteinases during Late Embryonic development. Dev. Dynamics 221: 37-47.
15. Iida, J., Pei, D., Kang, T., Simpson, M.A., Herlyn, M., Furcht, L. T., and McCarthy, J. B. 2001. Melanoma Chondroitin Sulfate Proteoglycan Regulates Matrix Metalloproteinase - Dependent Human Melanoma Invasion into Type I Collagen. J. Biol. Chem. 276: 18786- 18794.
16. Kang, T., Yi, J., Guo, A., Wang, X., Overall, C.M., Jiang, W., Elde, R., Borregaard, N., and Pei, D. 2001. Subcellular Distribution, Cytokine- and Chemokine- Regulated Secretion of Leukolysin / MT6-MMP /MMP-25 in Neutrophils. J. Biol. Chem. 276: 21960-21968.
17. Wang, X., Pei, D. 2001. Shedding of MT5-MMP by a Furin-Type Convertase: A Potential Mechanism of Down-Regulation. J. Biol. Chem. 276: 35953-60.
18. Jiang, A., Lehti, K., Wang, X., Weiss, S.J., Keski-Oja, J., and Pei, D. 2001. Regulation of Membrane-Type Matrix Metalloproteinase 1 Activity by Dynamin-Mediated Endocytosis. Proc. Natl. Acad. Sci. 98: 13693-8.
19. Pei, D. 2001. Matrix Metalloproteinases: An Introduction. Chinese J. of Biochem. & Mol.
Biol. 17：1-6.
20. Kang, T., Nagase, H., and Pei, D. 2002. Transactivation of ProMT3-MMP by Proprotein- Convertase Furin in Trans-Golgi Network. Cancer Res. 62: 675-681.
21. Lehti,K.., Lohi, J., Juntunen, M. M., Pei, D., Keski-Oja, J. 2002. Oligomerization through hemopexin and cytoplasmic domains regulate the activity and turnover of membrane-type-1 matrix metalloproteinase (MT1-MMP). J. Biol. Chem. 277:8440-8448.
22. Wilson, MJ, RG Sellars, C Wiehr, O Melamud, Pei, D and DM Peehl. 2002. Expression of
matrix metalloprotease-2 and 9 and their inhibitors, tissue inhibitors of metalloprotease-1 and
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