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李志远
编辑：生科院     发布时间：2019-04-16

Zhiyuan Li, M.D. Ph.D.

Principal Investigator & Chief

Laboratory of Ion Channels Research

Guangzhou Institute of Biomedicine and Health

Chinese Academy of Sciences

 190 Kai Yuan Avenue

 Guangzhou Science Park, China 510530

 20-32015345 (Lab), 20-32015241 (Office)

 20-32015299 (Fax), email: li_zhiyuan@gibh.ac.cn

EDUCATION AND TRAINING

 

Vanderbilt University, School of Medicine, Nashville, TN, USA

Post-doctoral Fellow at Pharmacology Department, Jul. 2000 to Dec. 2001

Work with Prof. Brash AR

 

Tokushima University, School of Medicine, Tokushima, Japan

Ph.D. at Nutrition Department, Sep. 1997 to Jun. 2000

Supervisor: Prof. Nakaya Yutaka

 

Central South University, XiangYa school of Medicine. Changsha, China

Ph.D. at Pharmacology Department, Sep. 1994 to Jun. 1997

Supervisor: Prof. Chen Xiu

 

Hunan Medical University, Changsha, China

Master of Science at Anatomy, Aug. 1991 to Jul. 1994

Mentor: Prof. Liu Yuming

 

Hunan Medical University, Changsha, China

M.D. at Clinical Medicine, Sep. 1983 to July 1988

 

ACADEMIC APPOINTMENTS

 

Sep. 2008 to Present, Faculty, Principal Investigator, Hundred Talent Scholar, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences

 

Jan. 2009 to Dec. 2013, Professor, Sheng-Hua Scholar, Director of Anatomy and Neurobiology, Xiang-Ya School of Medicine, Central South University

 

Jul. 2006 to Aug. 2008, Faculty, Assistant Professor, Pharmacological and Physiological Sciences, Saint Louis University

 

Jul. 2004 to Jul. 2006 Faculty, Research Assistant Professor, Pharmacological and Physiological Sciences, Saint Louis University

 

Jan. 2002 to Jun. 2004, Research Associate, Pharmacological and Physiological Science, Saint Louis University, Work with Prof. Egan TM

 

Sep. 1997 to Nov. 1999, Visiting Scientist, Nutrition Department, Tokushima University, Japan, Work with Dr. Niwa

 

Jul. 1994 to Jul. 1997, Lecturer, Hunan Medical University, China

 

Jul. 1988 to Jul. 1991, Teaching Assistant, Hunan Medical University, China

 

TEACHING

 

2008 -          Neurobiology, Cell Biology, Neuronal Stem Cells

2005 - 2008 Teaching electrophysiology and cell membrane biology for Ph.D. graduate

                    students of Saint Louis University School of Medicine , USA

1991 - 1997 Teaching in gross anatomy and neurobiology for 2nd year medical students

1988 - 1991 Teaching in gross anatomy for 1st and 2nd year medical students

 

GRADUATE STUDENTS GUIDE AND POSTDOCTORAL TRAINING:

 

Current:  8 Ph.D and 3 Master degree students at Lab

Graduated: 5 Ph.D and 7 Master degree students from lab at GIBH

Previous joint training in Saint Louis University:

Sarah C. Kucenas (Ph.D. Student)

David Stroup (Ph.D. Student)

Gina Jackson (Graduate student rotation in lab)

Steve Harris (Graduate student rotation in lab)

Keisuke Migita (Postdoctoral)

Damien S.K. Samways (Postdoctoral)

 

INVITED TALKS AND SEMINARS:

 

2014 International Conference on Translational Medicine, Changsha, China (2014 Oct.)

2014 International Summit on Genetic Medicine, Changsha, China (2014 May)

10th Central South Distract Neurosciences Meeting, Huaihua, China (2012 July)

Scholar Xiu Chen Mini Conference, Changsha, China (2012 June)

Rush University School of Medicine, Chicago, USA (2012 February)  

Aurora Biomed Ion Channel Retreat, Vancouver, Canada (2010 July)

Chinese Academy of Sciences Graduate College, Beijing (2010 July)

Central South University, Xian-Ya Medical College, Changsha, China (2010 April)

Hainan University, Medical School, Hainan (2009 November)

Central South University, Xian-Ya Medical College, Changsha, China (2009 October)

Guangzhou Institute of Biomedicine and Health, Chinese Academy Sciences, Guangzhou, China (2009 August)

Aurora Biomed Ion Channel Retreat, Vancouver, Canada (2009 July)

Hundred Talent Forum of Chinese Academy of Sciences, Beijing (2009 May)

Hundred Talent Forum of Chinese Academy of Sciences, Chengdu (2008 August)

Aurora Biomed Ion Channel Retreat, Vancouver, Canada (2008 June)

Central South University, Xian-Ya Medical College, Changsha, China (2007 November)

Guangzhou Institute of Biomedicine and Health, Chinese Academy Sciences, Guangzhou, China (2007 June)

AT Still University, Kirksville College of Osteopathic Medicine, Kirksville, MO (2006 November).

Southern Illinois University, School of Medicine, Carbondale, IL (2006 March)

Indiana State University, School of Medicine, Terre Haute, IN 47809 (2005 November)

Hunan Medical University, Changsha, China (1999 November)

4th Military Medical University, Xian, China (1994 October)

 

PRESENTATIONS

 

Hunan Key Lab of Neuronal Degeneration Diseases Conference (June 6 2015)

China-Canada Stem cell & Regenerative Medicine Workshop (May 29-30 2015)

1st Asia Ion Channel Retreat, Guangzhou, China (Nov. 05-07 2014)

18th Congress of the International Anatomists, Beijing, China (Aug. 08-10 2014)

9th Ion Channel Retreat, Vancouver, Canada (June 24-26, 2013)

11th ISSCR , Boston, USA (June 12-16, 2013)

10th ISSCR , Yokuhama, Tokyo, Japan (June 13-17, 2012)

4th International Stem Cell Conference, Guangzhou, China (December 2011)

2nd International Stem Cell Conference, Guangzhou, China (December 2009)

14th SBS Annual Conference, St. Louis, MO (April 2008)

The Society for Neuroscience 34th Annual Meeting, San Diego, CA (Oct. 22 – 27, 2004)

The Society for Neuroscience 33rd Annual Meeting, New Orleans, LA (Nov. 8 – 12, 2003)

The 14th World Congress of Pharmacology, San Francisco, CA (Jul. 7 – 12, 2002)

The 7th International Conference on Eicosanoids and other Bioactive Lipids in Cancer, Inflammation and Related Diseases, Nashville, TN (Oct. 14 – 17, 2001)

The 16th Shiguguo Conference on Biochemistry, Naruto, Japan (May 1999)

The 14th International Conference on Morphology, Beijing, China (Oct. 1997)

The 10th National Conference on Anatomy, Xian, China (Oct. 1994)

EDITORIAL BOARD MEMBERS

Scientific Reports (Nature Publishing Group)

Journal of stem cells and clinical practice

Journal of Neurorestoratology

Ion Channel Retreat (Scientific Advise Board)

Hunan Key Lab of Neuronal degeneration diseases (Scientific Advise Board)

MANUSCRIPTS REVIEWER FOR

Journal of Cardiovascular Pharmacology

The Journal of Neuroscience

Cell Regeneration

The Journal of Biological Chemistry

Biophysical Journal

Neuroscience

Apoptosis

Current Chemical Genetics

回国后获取科研经费（共计3402.5万）

  1. 2008年中国科学院海外招聘研究员启动经费，500万，2008年9月1日-

  2. 2009年中国科学院择优“百人计划”，200万，09年1月1日-13年12月12日。

  3. 2009年中南大学“升华学者”，100万，2009年1月1日-2013年12月12日。

  4. 2010年中国科学院广东省全面战略合作项目，项目名称“心血管化学创新新药JBTA的临床研究”，总经费40万，2010年01月―2012年12月。

  5. 2010年教育部博士点基金，6万，2010年01月―2012年12月。

  6. 2010年中国科学院佛山产业技术创新与育成中心生物医药科技产业中心项目，项目名称“干细胞分选设备的应用开发”，200万，2011年01月―2012年12月。

  7. 2010年中国科学院院地合作专项储备项目，项目名称“蛋白A免疫吸附系统”，总经费740万，2011年01月―2013年12月。

  8. 2011年国家自然科学基金面上项目，项目名称“与疼痛相关的P2X离子通道的分子结构和功能的研究”。60万，2012年1月—2015年12月。项目编号：81171037。

  9. 2011年国家重点基础研究发展973计划， 子课题名称“人多能干细胞向神经细胞分化的功能性研究”，子课题号2012CB966404，720万，2012年1月—2016年12月。

  10. 2011年中国科学院支撑服务国家战略性新兴产业科技行动计划专项项目，项目名称“药物开发的临床试验和GCP平台 ”，400万，2012年01月—2014年12月。

  11. 2012年佛山市院市合作专项，项目名称“自动化磁珠分离设备的应用开发”，40万，2013年1月—2014年12月，2012HY100062。

  12. 2012年广东省中国科学院全面战略合作项目，项目名称“自动化磁珠分离设备的应用开发”，40万，2013年1月—2014年12月，2012B091100274。

  13. 2013年中国科学院外籍青年科学家计划，外国青年专家Damien Stephen Kenneth Samways，26.5万，合作研究员，2012YESA0014。

  14. 2013年国家自然基金委外国青年学者研究基金”项目，外国青年学者Damien Stephen Kenneth Samways，20万，312111170。

  15. 2014年广东省外专研究基金”项目，外国学者Dr. England 等，35万。

  16. 2014年长沙市急需紧缺型领军人才计划，100万。

  17. 2015年省科技厅公益项目，75万。

  18. 2015年广东省产学研项目，脐带间充质干细胞治疗股骨头缺血性坏死干细胞制剂的临床前研究，100万。

  19. 2015年湖南省科技厅创新平台与人才计划（应用基础研究），源于帕金森病人iPS神经元功能研究和间充质干细胞临床应用，2015JC3129，5万元。

  20. 脐带间充质干细胞治疗年龄相关性黄斑变性的研究，2016年01月-2018年12月，20万元。

  21. 人脑组织疾病生物标记与诊断技术的研发，2016年01月-2018年12月，50万元。

  22. 长沙高新区第五批“555人才计划”创新类，80万元。

  23. 2015年度留学人员科技活动项目择优资助经费，6万元。

  24. 2015年市级引进海外人才与智力项目计划，3万元。

     

GRANTS SUPPORT

 

NSFC Oversea Excellent Talent (PI)

01/01/13-12/31/13

RMB 200,000

 

CAS Oversea Foreign Talent (PI)

01/01/13-12/31/13

RMB 265,000

 

CAS-Fusan City Collaboration Grant (PI)

01/01/13-12/30/14

RMB 400,000

 

CAS-Guangdong Province Collaboration Grant (PI)

01/01/13-12/30/14

RMB 400,000

 

NSFC (PI)

01/01/12-12/30/15

RMB 600,000

 

973 Projects (PI)

01/01/12-12/30/16

RMB 7,200,000

 

Creation Grant of CAS (PI)

01/01/12-12/30/15

RMB 4,000,000

 

Creation Grant of CAS (PI)

01/01/11-12/30/14

RMB 400,000

 

Applied Grant of CAS (PI)

09/01/11-08/30/13

RMB 2,000,000

 

Yuan-Di Collaboration Grant (PI)

12/01/11-11/30/13

RMB 400,000

 

PhD Program of Chinese Education Department (PI)

01/01/10-12/30/12

RMB 80,000

 

Hundred Talent Plan CAS (PI)

05/01/09-04/30/12

RMB 2,000,000

 

GIBH Start up package (PI)

10/01/08-09/30/13

RBM 5,000,000

 

NIH Grant, R 01 HL056236 -08 (co-PI)

07/01/06-06/30/10

NIH/NHLBI            $1,125,000

Characterization of Cardiovascular Purinoceptors

 

NIH Grant, R 01 GM070925-01 (Key person, Egan, PI)

04/01/04-03/31/08

NIH/NIGMS           $950,898

Dynamics of Gating and Conduction of ATP-Gated Ion Channels

 

NIH Grant, R 01 HL056236 -07 (Key person, Egan, PI)

04/01/01-03/31/06

NIH/NHLBI            $855,000

Characterization of Cardiac Purioceptors

 

Chinese Education Ministry, CEM2000-479 (PI)

01/01/00-12/31/01, RMB 150,000 (Chinese Yuan)

 

National Natural Science Foundation of China, NSFC30070253 (main participant)

07/01/00-06/30/04, RMB 210,000

 

National Natural Science Foundation of China,

NSFC30100098 (participant)

07/01/02-06/30/07, RMB 290,000

 

HONOR/AWARDS

 

First Prize of Hunan Medical Science and Technology Awards by Hunan Medical Association. Certificate No. 20020104 (2003)

Second Prize of the Province Science and Technology Progress Awards by Hunan Province Government. Certificate No. 2003230070-2-04 (2003)

Excellent presentation award of 14th World Congress of Pharmacology (2002, USA)

Otsuka Ph.D Scholarship (1997-1999, Japan)

Second Prize of excellent paper by Science and Technology Community of Hunan, China 022-2067 (1996).

Excellent Essay by Chinese Anatomy Society (1995)

 

MEMBERSHIP

 

  Society for Neuroscience (USA)

  Biophysical Society (USA)

  Society for Stem Cells Research (USA)

  Society for Cell Biology (China)

  Society for Anatomy (China)

  Society for Neurobiology (China)

 

INVITED ARTICLE/BOOK/CHAPTERS

 

  • Regional Anatomy (Chapters in Book, 2013) ISBN 978-7-117-17197-7/R.17198

  • Regional Anatomy Guide (Editor-in-vice chief, 2013) ISBN 978-7-5023-7690-1

  • Jie Y, Liang X, Li Z. The antibacterial drug discovery. (Drug Discovery: ISBN 978-953-51-0906-8)

  • Liang X, Xiao Y, Li Z. P2X receptors as new drug therapeutic targets. (Drug Development: ISBN 979-953-307-657-6).

  • Long Y and Li Z. Drug screening and drug safety evaluation by patch clamp technique. (Patch Clamp Technique: ISBN 979-953-307-386-5).

    Li Z, Harris S and Egan T M (2009) P2X Receptors. In: Squire LR (ed.)  Encyclopedia of Neuroscience, volume 7, pp. 349-354. Oxford: Academic Press.

    Li Z & Egan TM. P2X Receptor. IN:Encyclopedia of Neuroscience. G. Adelman & B. H. Smith, Ed., Elsevier, Boston. ISBN:0-444-51432-5. Publication date: 2004.

    Samways DSK, Li Z and Egan TM. Binding, gating and conduction of ATP-gated P2X receptor channels. ISBN: 81-7736-254-2. 2006:419-443

    Li Z (Editor-in-chief). (1996). Laboratory Guide for Human Anatomy. ISBN7-5357-2237-7 (Text book for Medical School)

    Li Z (Chapters in Book) Gross Anatomy.

     

PUBLICATIONS

 

  1. Peer-Reviewed Articles

     

  1. Li C, Ma W, Yin S, Liang X, Shu X, Pei D, Egan TM, Huang J, Pan A, Li Z. (2016) Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3. Traffic. 2016 Jan 27. doi: 10.1111/tra.12379. [Epub ahead of print]

  2. Liu J, Gao C, Chen W, Ma W, Deng S, Li X, Shi Y, Zhang H, Zhang L, Long Y, Xu H, Guo X, Lai L, Pan G, Chen Y, Liao W, Li Z (2016) CRISPR/Cas9 Facilitates Investigation of Neural Circuit Disease using Human iPSCs: Mechanism of Epilepsy Caused by an SCN1A Loss-of-function Mutation. Translational Psychiatry. Jan 5;6:e703. doi: 10.1038/tp.2015.203

  3. Ma W, Li C, Yin S, Liu J, Gao C, Lin Z, Huang R, Huang J, Li Z. (2015) Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in Human hepatoma cells. Free Radical Biology & Medicine. 89: 1003–13.

  4. He X, Deng F, Ge Jin, Yan X, Pan A, Li Z. (2015) Effects of total saponins of Panax notoginseng on immature neuroblasts in the adult olfactory bulb following global cerebral ischemia/reperfusion. Neural Regeneration Research. 10(9):1450-6.

  5. Yang Y, Xie M, Li J, Hu X, Patrylo PR, Luo X, Cai Y, Li Z, Yan X. (2015). Prenatal genesis of layer II doublecortin expressing neurons in neonatal and young adult guinea pig cerebral cortex. Front Neuroanat. 9, 109.

  6. Zhou Y, Hou G, He S, Xiao Z, Xu H, Qiu Y, Jiang S, Zheng H, Li Z. (2015) Psora-4, a Kv1.3 Blocker, enhances differentiation and maturation in neural progenitor cells. CNS Neuroscience & Therapeutics 21(7):558-67.

  7. Gao C, Yu Q, Xu H, Zhang L, Liu J, Jie Y, Ma W, Samways DS, Li Z. (2015) Roles of the lateral fenestration residues of the P2X4 receptor that contribute to the channel function and the deactivation effect of ivermectin. Purinergic Signal. PMID: 25847072

  8. Wang X, Zhong X, Li Z, Wang H, Zhang J, Li F, Zhang J, Dai R, Zhou X, Li C, Li Z, Bi F. (2015) Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats. BMC Neurosci.16: 14.

  9. Liu C, Yang Y, Hu X, Li J, Zhang X, Cai Y, Li Z, Yan X. (2015). Ontogenesis of NADPH-diaphorase positive neurons in guinea pig neocortex. Front Neuroanat. 9, 11.

  10. Zhang L, Deng S, Li Z. (2015) ATP Binding and Channel Activation in P2X Receptors. Receptors & Clinical Investigation. 2(1), 10-14800.

  11. Deng S, Hou G, Xue Z, Zhang L, Zhou Y, Liu C, Liu Y, Li Z. (2015) Vitamin E isomer δ-tocopherol enhances the efficiency of neural stem cell differentiation via L-type calcium channel. Neurosci Lett. 12;585C:166-170.

  12. Jie Y, Zhang L, Xu H, Gao C, Ma W, Li Z. (2014) Involvement of the left-flipper-to-dorsal-fin interface of the zebrafish P2X4 receptor in ATP binding and structural rearrangement. Neurosci Lett. 582C:1-5.

  13. 李美丽，邓思浩，段娟，贺 旭，牟琳，李志远. (2014) 海马内注射LPS后诱导大鼠脑内BACE-1的表达变化. 神经解剖学杂志 , 30(5):581-586

  14. Deng X, Li M, Ai W, He L, Lu D, Patrylo PR, Cai H, Luo X, Li Z, Yan X. (2014) Lipolysaccharide-Induced Neuroinflammation Is Associated with Alzheimer-Like Amyloidogenic Axonal Pathology and Dendritic Degeneration in Rats. Adv Alzheimer Dis. 3(2):78-93.

  15. Li W, He S, Zhou Y, Li Y, Hao J, Zhou X, Wang F, Zhang Y, Huang Z, Li Z, Loh HH, Law PY, Zheng H. (2014) Neurod1 Modulates Opioid Antinociceptive Tolerance via Two Distinct Mechanisms. Biol Psychiatry. S0006-3223(14)00374-6. doi: 10.1016

  16. Zhang L, Xu H, Jie Y, Gao C, Chen W, Yin S, Samways DS, Li Z. (2014) Involvement of Ectodomain Leu 214 in ATP Binding and Channel Desensitization of the P2X4 Receptor. Biochemistry. 53(18): 3012-3019.

  17. Chen W, Liu J, Zhang L, Xu H, Guo X, Deng S, Liu L, Yu D, Chen Y, Li Z. (2014) Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique. Scientific Reports. 4:5404. doi: 10.1038/srep05404.

  18. Long Y, Chen W, Lin Z, Sun H, Xia M, Zheng W, Li Z. (2014) Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide. Eur J Pharmacol. 737C: 202-209.

  19. Samways DS, Li Z, Egan TM. (2014) Principles and properties of ion flow in P2X receptors. Front Cell Neurosci. 8: 6. doi: 10.3389/fncel.2014.00006

  20. 冯莹，李志远.成年哺动物皮质区神经发生的研究进展.现代生物医学进展. 14(29):5797－5800.

  21. Liang X, Xu H, Li C, Yin S, Xu T, Liu J, Li Z. (2013) Functional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptor. PLoS One. 8(8): e70629.

  22. Li C, Long Y, Lin Z, Jie Y, Xiao Y, Yang L, Sun J, Ren Y, Chen L, Li Z. (2013) New strategy for high throughput screening of anti-influenza virus M2 ion channel inhibitors. Curr Pharm Des. 19(28): 5146-5155.

  23. Long Y, Lin Z, Xia M, Zheng W, Li Z. (2013) Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride. Toxicol Appl Pharmacol. 267(2): 155-166.

  24. Su H, Wang L, Cai J, Yuan Q, Yang X, Yao X, Wong W M, Huang W, Li Z, Wan J B, Wang Y, Pei D, So K F, Qin D, Wu W. (2013) Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle. Stem Cell Res. 11(1): 529-539.

  25. Hu X, Chen D, Cui Y, Li Z, Huang J. (2013) Targeting microRNA-23a to inhibit glioma cell invasion via HOXD10. Sci Rep. 3:3423.

  26. Pan A, Li M, Gao J, Xue Z, Li Z, Yuan X, Luo D, Luo X, Yan X. (2013) Experimental epidural hematoma causes cerebral infarction and activates neocortical glial and neuronal genesis in adult guinea pigs. J Neurosci Res. 91(2): 249-261.

  27. Lu D, He L, Xiang W, Ai W, Cao Y, Wang X, Pan A, Luo X, Li Z, Yan X. (2013) Somal and dendritic development of human CA3 pyramidal neurons from midgestation to middle childhood: a quantitative Golgi study. Anat Rec (Hoboken). 296(1): 123-132.

  28. Su H, Wang L, Huang W, Qin D, Cai J, Yao X, Feng C, Li Z, Wang Y, So K, Pan G, Wu W, Pei D. (2013) Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells. Stem Cell Res. 10(3): 338-348.

  29. 杨 燕, 李明, 薛志琴, 邓思浩, 严小新, 李志远. (2013) BrdU免疫荧光染色方法的改进.中国医药指南. 2 (11): 60-62.

  30. Zhao X, Jie Y, Rosenberg MR, Wan J, Zeng S, Cui W, Xiao Y, Li Z, Tu Z, Casarotto MG, Hu W. (2012) Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors. Antiviral Res. 96(2): 91-99.

  31. Xiao Y, Liang X, Li Z. (2012) A comparison of the performance and application differences between manual and automated patch-clamp techniques. Curr Chem Genomics. 6: 87-92.

  32. Li F, Li M, Cao W, Xu Y, Luo Y, Zhong X, Zhang J, Dai R, Zhou X F, Li Z, Li C. (2012) Anterior cingulate cortical lesion attenuates food foraging in rats. Brain Res Bull. 88(6): 602-608.

  33. Deng X, Ai W, Lei D, Luo X, Yan X, Li Z. (2012) Lipopolysaccharide induces paired immunoglobulin-like receptor B (PirB) expression, synaptic alteration, and learning-memory deficit in rats. Neuroscience. 209: 161-170.

  34. Xie H, Zeng L, Zeng S, Lu X, Zhang G, Zhao X, Cheng N, Tu Z, Li Z, Xu H, Yang L, Zhang X, Huang M, Zhao J, Hu W. (2012) Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization. Eur J Med Chem. 52: 205-212.

  35. Li W, Wang X, Fan W, Zhao P, Chan Y C, Chen S, Zhang S, Guo X, Zhang Y, Li Y, Cai J, Qin D, Li X, Yang J, Peng T, Zychlinski D, Hoffmann D, Zhang R, Deng K, Ng K M, Menten B, Zhong M, Wu J, Li Z, Chen Y, Schambach A, Tse H F, Pei D, Esteban M A. (2012) Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes. Hum Mol Genet. 21(1): 32-45.

  36. Pan A, Wu H, Li M, Lu D, He X, Yi X, Yan X, Li Z. (2012) Prenatal expression of purinergic receptor P2X3 in human dorsal root ganglion. Purinergic Signal. 8(2): 245-254.

  37. Li H, Li C, Dai R, Shi X, Xu J, Zhang J, Zhou X, Li Z, Luo X. (2012) Expression of acetylated histone 3 in the spinal cord and the effect of morphine on inflammatory pain in rats. Neural Regen Res. 7(7):517-522.

  38. Liu Y, Xiao Y, Li Z. (2011) P2X7 receptor positively regulates MyD88 dependent NF-κB activation. Cytokine. 55(2): 229-236.

  39. Liang X, Li Z. (2010) Ion channels as antivirus targets. Virol Sin. 25(4): 267-280.

  40. Hu W, Zeng S, Li C, Jie Y, Li Z, Chen L. (2010) Identification of hits as matrix-2 protein inhibitors through the focused screening of a small primary amine library. J Med Chem. 53(9): 3831-3834.

  41. Cai J, Li W, Su H, Qin D, Yang J, Zhu F, Xu J, He W, Guo X, Labuda K, Peterbauer A, Wolbank S, Zhong M, Li Z, Wu W, So K F, Redl H, Zeng L, Esteban M A, Pei D. (2010) Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells. J Biol Chem. 285(15): 11227-11234.

  42. Zhang W, Xu J, Liu F, Li C, Jie Y, Chen S, Li Z, Liu J, Chen L, Zhou G (2010).A Heterodimers of Histidine and Amantadine as Inhibitors for Wild Type and Mutant M2 Channels of Influenza A. Chinese J Chem.

  43. Wen G, Hui W, Dan C, Xiao-Qiong W, Jian-Bin T, Chang-Qi L, De-Liang L, Wei-Jun C, Li Z, Xue-Gang L. (2009) The effects of exercise-induced fatigue on acetylcholinesterase expression and activity at rat neuromuscular junctions. Acta Histochem Cytochem. 42(5): 137-142.

  44. Yang L, Li C, Chen L, Li Z. (2009) An agarose-gel based method for transporting cell lines. Curr Chem Genomics. 3: 50-53.

  45. Pan A , Lu D, Luo X, Chen L, Li Z. (2009) Formalin-induced increase in P2X3 receptor expression in dorsal root ganglia: implications for nociception. Clin Exp Pharmacol Physiol. 36(8): e6-e11.

  46. Li Z, Harris S , Egan TM. (2009) P2X Receptors. Encyclopedia of Neuroscience. 7: 349-354.

  47. 孙娟娟, 李楚芳, 徐伟, 李志远, 刘劲松, 陈凌. A型流感病毒H5N1的M2离子通道稳定细胞株的建立. 生物工程学报；2008，11.

  48. Li Z, Liang D, Chen L. (2008) Potential therapeutic targets for ATP-gated P2X receptor ion channels. Assay Drug Dev Technol. 6(2): 277-284.

  49. Samways DS, Migita K, Li Z, Egan TM. (2008) On the role of the first transmembrane domain in cation permeability and flux of the ATP-gated P2X2 receptor. J Biol Chem. 283(8): 5110-5117.

  50. Li Z, Harris S , Egan TM. (2007) P2X Receptors. Encyclopedia of Neuroscience. G. Adelman & B. H. Smith, Ed. Elsevier, Boston.

  51. Egan TM, Samways DS, Li Z. (2006) Biophysics of P2X receptors. Pflugers Arch. 452(5): 501-512.

  52. Li Z, Migita K, Samways DS, Voigt MM, Egan TM. (2004) Gain and loss of channel function by alanine substitutions in the transmembrane segments of the rat ATP-gated P2X2 receptor. J Neurosci. 24(33): 7378-7386.

  53. Li Z, Egan TM. (2003) P2X Receptor. Encyclopedia of Neuroscience.  876-890.

  54. Kucenas S, Li Z, Cox JA, Egan TM, Voigt MM. (2003) Molecular characterization of the zebrafish P2X receptor subunit gene family. Neuroscience.  121(4): 935-945.

  55. Samways DS, Li Z, Egan TM. Binding, gating and conduction of ATP-gated ion channels. IN: Biophysical Aspects of Ligand-gated Ion Channel Receptor Superfamilies, HR Arias, Ed., Research Signpost (NY).

  56. Li Z, Chen X, Niwa Y, Sakamoto S, Nakaya Y. (2001) Involvement of Ca2+-activated K+ channels in ginsenosides-induced aortic relaxation in rats. J Cardiovasc Pharmacol. 37(1): 41-47.

  57. Li Z, Nakaya Y, Niwa Y, Chen X. (2001) K(Ca) channel-opening activity of Ginkgo Biloba extracts and ginsenosides in cultured endothelial cells. Clin Exp Pharmacol Physiol. 28(5-6): 441-445.

  58. Li Z, Niwa Y, Sakamoto S, Shono M, Chen X, Nakaya Y. (2000) Induction of inducible nitric oxide synthase by ginsenosides in cultured porcine endothelial cells. Life Sci. 67(24): 2983-2989.

  59. Li Z, Niwa Y, Sakamoto S, Chen X, Nakaya Y. (2000) Estrogen modulates a large conductance chloride channel in cultured porcine aortic endothelial cells. J Cardiovasc Pharmacol. 35(3): 506-510.

  60. Li Z, Niwa Y, Rokutan K, Nakaya Y. (1999) Expression of endothelin-1 in macrophages and mast cells in hyperplastic human tonsils. FEBS Lett. 457(3): 381-384.

  61. Li Z, Chen X. (2000) Chloride channels in vascular endothelial cells- electrophysiological characters and functions. Life Sci. 5(6):386-404.

  62. Li Z, Luo X. (1999) Effect of ischemia-reperfusion injuries on the expression of nitric oxide synthase in rat retina. Bull of Hunan Med Univ. 12(24):495-496.

  63. Chen X, Liu L and Li Z. (1997) Cardiovascular protective effects and NO-mediated cerebrovasorelaxant effects of extract of ginkgo biloba leaves. Zhonghua Yi Xue Za Zhi. 78(9): 692-695.

  64. Li Z, Liu L, Liu Z, Liu Y. (1996) Immunohistochemical study of C-fos expression in the process of myocardium hypertrophy in culture. Chinese J Histochem Cytochem. 5(1): 382-386.

  65. Li Z, Liu L, Liu Z, Liu Y. (1996) Histochemical distribution of nitric oxide synthase in rabbit lung and effect of ischemia on its activity. Bull.of Hengyang Med Coll. 24(3): 46-48.

  66. Li Z, Liu L. (1996) The study of C-myc and P53 in cardiovascular diseases. Adv Cardiovas Dis. 17(5): 158-161.

  67. Luo X, Li Z, Wei H, Liu S. (1996) The influence of pressure on human lamina cribrosa cell and its nitric oxide synthase. Chin J Ophthalmol. 32(1): 65-68.

  68. Hu W, Li Z, Liu Y. (1996) Effects of endotoxemia on the nitric oxide synthase activaties in rat myocardium. Bull.of Hengyang Med Coll. 24(3): 39-42.

  69. Li Z, Liu L, Cai W. (1994) The gene expression of P53 and C-myc in the cultured of hypertrophy of neonatal myocardial cells of rats-in situ hybridization study. Chinese J Histochem Cytochem. 3(6): 263-268.

     

B. Abstract

 

  1. Li Z, Deng S, Hou G, Pan A. Vitamin E isoform δ-tocopherol enhanced the efficiency of neural stem cell differentiation via L-type calcium channel. Annals of Anatomy,196S1 (2014) .http://www.elsevier.com/locate/aanat

  2. Li Z, Migita K, Samways DSK, Voigt MM and Egan TM. (2004) Gain and loss of channel function by alanine-substitutions in the transmembrane segments of the ATP-gated P2X2 receptor. Program No. 958.3. 2004 Abstract Viewer/Itinerary planner. Washington, DC: Society for Neuroscience. Online.

  3. Li Z, Migita K, Voigt MM, Khakh BS, Egan TM. (2003) Amino acid residues involved in calcium permieability in the second transmembrane domain of the P2X4 receptor. Program No. 250.11 2003. Washington, DC: Society for Neuroscience. Online.

  4. Voigt MM, Kucenas S, Li Z, Migita K, Egan TM, Cox JA. (2003) Molecular characterization of the zebrafish P2X subunit gene family. Program No. 250.11 2003. Washington, DC: Society for Neuroscience. Online.

  5. Li Z, Migita K, Voigt MM, Egan TM. (2002) The effect of alanine substitutions in the second transmembrane domain of the P2X2 receptor on the potency of ATP. The Pharmacologist.  Jun 449(2, supplement 1): LB106.

  6. Li Z, Brash AR. (2001) Expression of human 12R-Lipoxygenase in transgenic murine epidermis. Inflammation and related disease. P 79.

C. Patent

  1. 周国春, 陈 凌, 李志远, 陈绪林, 徐 静, 刘劲松. 具有抑制和阻断M2离子通道活性的化合物及其应用. (101531637A)

  2. 程娜，李志远，徐慧娟. 一种高效评估药物对hERG通道安全性的评价方法 (201210201680.4)

  3. 揭艳玲，李志远，徐慧娟. 记录槽 (201220480049.8)

  4. 李志远，程娜，陈家琪，梁洞泉. 分离器（磁圈板）(201330030300.0)

  5. 李志远，程娜，陈家琪，梁洞泉. 分离器（磁棒板）(201330030240.2)

  6. 李志远，程娜，陈家琪，梁洞泉. 一种微孔板式磁珠分离器 (201320057660.4)

  7. 李志远，程娜，陈家琪，梁洞泉. 一种微量磁珠分离器 (2013 2 0057672.7)

  8. 李志远，尹士魁，揭艳玲. 一种质粒提取吸附柱 (201320179011.1)

  9. 李志远，揭艳玲，尹士魁，徐慧娟. 一种改进的防震台 (2013 2 0497741.6)

  10. 李志远，尹士魁，李彩月，马文波 一种新型导流柱式抗体结合收集管 (201320497668.2)

  11. 李志远，徐慧娟，揭艳玲，粱欣 一种改进的细胞冻存盒 (201320627288.6)

  12. 李志远，梁欣，尹士魁. 一种能快速增加细胞膜通透性从而快速破膜形成高阻封接的方法 (201310473138.9)

  13. 李志远，揭艳玲，徐慧娟，梁欣. 胺类化合物及其制备方法和在制备抗流感病毒药物中的应用 (201310585676.7)

  14. 李志远，邓思浩，薛志琴，贺旭，钟小林，胡杏. 一种促进大鼠神经干细胞分化的培养基及其使用方法 (201410288590.2)

  15. 李志远，邓思浩，曹文宇，卢大华，徐杨. 一种神经干细胞的冻存液及其使用方法 (201510037248.X)

  16. 李志远，胡建光，曹文宇，邓思浩，卢大华，徐杨. 一种新型尸体标本保存液(201510037247.5)

  17. 李志远，周雨叶，萧卓. 有效抑制小鼠KCNA3基因表达的DNA、shRNA及其应用( 201510148971.5)

  18. 李志远，周雨叶，萧卓. 神经干细胞分化培养基及应用 (2015101146927)

  19. 李志远，李彩月，马文波. 一种避光的载玻片保存盒子 (201510280599.3)

  20. 李志远，李彩月，马文波. 一种高效转染HaCaT细胞的方法 (201510279140.1)

  21. 李志远，李彩月，马文波. 一种高效提取小鼠皮肤组织TRPV3蛋白的方法 (201510290429.3)

  22. 李志远，高超，刘静馨. 一种快速增加细胞膜通透性的细胞内液及其方法 (201510280313.1)

  23. 尹士魁，李彩月，李志远. 一种半自动吸头分装仪（201510416924.4）

  24. 李志远，黄荣奇. 丹皮酚在制备激活hERG离子通道药物中的应用(201510955053.3)

  25. 李志远，马文波，邓思浩，李彩月，陈旦，刘亮. 一种提取古代生物骨骼DNA的裂解液及方法.(201610014145.6)

 

 

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