招生方向：生物学（生物化学与分子生物学）
李朝阳 博士，教授，博士研究生导师
联系方式：
通讯地址：广州医科大学附属肿瘤医院肿瘤研究所
广东省广州市横枝岗路78号， 邮编：510095
电话：15871683145 （办公室），18186152890（手机）
研究兴趣：
主要围绕病毒感染和肿瘤发生进行研究，尤其是朊病毒蛋白的表达与炎性反应的关联和促进肿瘤的发生发展机制；肿瘤微环境；肿瘤免疫治疗；肿瘤个体化治疗；朊病毒等神经退行疾病的致病机理。
教育经历:
1997,8-2001,8 美国宾西法尼亚州立大学, 哲学博士
1991,9-1994,7 中国科学院动物学研究所, 理学硕士
1987,9-1991,7 南京大学, 理学学士
工作经历:
2018.12-至今：广州医科大学附属肿瘤医院，教授
2011.10-2018.12 中科院武汉病毒所分子病毒中心,研究员
2010,8-2011,9 美国克里夫兰临床医院, Research Associate
2003,11-2010,8 美国凯斯西部保留地大学, Research Associate
2003,6-2003,10 美国约翰霍普金斯大学, Research Associate
2001,8-2003,5 美国凯斯西部保留地大学, Research Associate
1994,7-1997,8 中国科学院上海昆虫学研究所, 技术员
获奖情况:
1. 2000, 12 美国昆虫学会主席奖
2. 2000年， 美国宾夕法尼亚州立大学研究生国际参会旅行奖。
3. 2015年，中国微生物学术年会人口健康和微生物报告一等奖。
4. 2016年，中国微生物学术年会人口健康和微生物报告一等奖。
5. 2013年，入选中国科学院“百人计划”特聘研究员。
学会任职:
2013-至今 中国细胞学会细胞结构与细胞行为分会理事
2017-至今 湖北省生物化学学会理事
主持项目
1. 自然科学基金面上项目：朊蛋白（PrP）促进整合素α5（Integrin α5）表达介导肝癌细胞肝内转移的分子机制（主持人）2021.1.1-2024.12.30
2. 科技部重大专项蛋白质重点研发计划：高致病性病毒转录复制过程关键蛋白质机器的发现与组装模式，（项目骨干），2018-7-2022,12.
3. 中科院战略性先导项目A：原发性肝癌抗肿瘤药物的生物标志物与药物靶标的发现与确证，项目执行期： 2017-2018（主持人）。已结题。
4. 自然科学基金面上项目：磷脂酰肌醇锚合成缺陷通过朊病毒蛋白（PrP）影响胰腺癌细胞转移的机制. 2017.1-2020.12（主持人）。
5. 病毒学国家重点实验室“病毒学前沿科学重点研究项目： 寨卡病毒感染致神经病变机制”，项目执行期2016.7-2018.12。（主持人）。已结题。
6. 自然科学基金重大应急项目（81590764）， 埃博拉病毒感染的免疫病理研究。（参与人）2015.0701-2017.12.31. 已结题。
7. 湖北省科技厅重点项目(2015CFA087)，细胞型朊病毒蛋白或前朊病毒蛋白作为胰腺导管腺癌预后生物标记的研究，10万, 2015,1,1-2016,12,31。已结题。
8. 中科院武汉病毒所135培育项目, 人类烈性病毒感染的核糖核酸生物学研究，10万。已结题。
9. 百人计划匹配 中国科学院武汉病毒所 （承担人）2013.1.1-2015.12.30。已结题。
10. 科技部973项目(批准号:2013CB911102)：重要病毒转录复制蛋白复合体的结构功能研究（课题骨干）2013.1.1-2017.12.30。已结题。
11. 自然科学基金面上项目(批准号: 31270209)：突变型朊蛋白致病机理研究 （主持人）2013.1.1-2016.12.30。已结题。
12. 自然科学基金面上项目(批准号: 81172376)：pro-prion对胰腺癌恶性转化的机理研究 （主持人）2012.1.1-2015.12.30。已结题。
编委任职：
1. 2016.8-现在: Frontiers in Neurodegeneration, Frontiers in Neuroscience, Neurology and Psychiatry (编委)。
2. 2020.4.20-至今：Frontiers Aging Neuroscience(编委)。
3. 2017.7-现在: 微生物和感染杂志 (编委)。
发表论文:
1. Run Shi#*, Zhe Zhang#, Ankai Zhu#, Xingxing Xiong, Jie Zhang, Jiang Xu, Man-Sun Sy, Chaoyang Li*, Targeting Type I Collagen for Cancer Treatment, International Journal of Cancer, 2022, Feb 28. doi: 10.1002/ijc.33985. (accepted for publication). (第一通讯作者).
2. Run Shi*, Shanshan Gao, Jie Zhang, Jiang Xu2, Linda M. Graham, Xiaowen Yang*, and Chaoyang Li*, Collagen prolyl 4-hydroxylases modify tumor progression. Acta Biochim Biophys Sin, 2021, July, 53(7), 805-14. (第一通讯作者).
3. Ming Shao, Run Shi, Zhen-Xing Gao, Shan-Shan Gao, Jing-Feng Li, Huan Li, Shu-Zhong Cui, Wei-Min Hu, Tian-Yun Chen, Gui-Ru Wu, Jie Zhang, Jiang Xu, Man-Sun Sy, and Chaoyang Li*, Crizotinib and Doxorubicin Cooperatively Reduces Drug Resistance by Mitigating MDR1 to Increase Hepatocellular Carcinoma Cells Death, Frontiers in Oncology, 2021, May, 18;11:650052. doi: 10.3389/fonc.2021.650052. eCollection 2021. (通讯作者).
4. Huan Li, Ren Wang, Ze Yu, Run Shi, Jie Zhang, Shanshan Gao, Ming Shao, Shuzhong Cui, Zhenxing Gao, Jiang Xu, Man-Sun Sy, Chaoyang Li*, Tumor Necrosis Factor a Reduces SNAP29 Dependent Autolysosome Formation to Increase Prion Protein Level and Promote Tumor Cell Migration. Virological Sinica, 2021, Jun, 36：458-75. (通讯作者).
5. Shi R, Gao S, Smith AH, Li H, Shao M, Shangguan J, Zhang J, Xu J, Ye J, Graham LM*, Li C*, Superoxide-induced Type I collagen secretion depends on prolyl 4-hydroxylases, BBRC, 2020, Sep. 529(4), 1011-7. (第一通讯作者).
6. Ke J, Wu G, Zhang J, Li H, Gao S, Shao M, Gao Z, Cao Y*, Sy M, Yang X*, Xu J*, Li C*, Melanoma migration is promoted by prion protein via Akt-hsp27 signaling axis, BBRC, 2020, Feb 7, 523(2)：375-381. (第一通讯作者).
7. Luo Z, Gao G, Ma Z, Liu Q, Gao X, Tang X, Gao Z, Li C*, Sun T, Cichoric Acid from Witloof Inhibit Misfolding Aggregation and Fibrillation of hIAPP. Int J Biol Macromol. 2020， 148： 1272-9. （共同通讯作者）.
8. Run Shi, WeiminHu, Yan Zhang，Shanshan Gao, Andrew H. Smith, Jun Ye, Lili Cai, Linda M. Graham*, Chaoyang Li*, Ascorbate inducible N259 glycans on prolyl 4-hydroxylase subunit α1 promote hydroxylation and secretion of Type I collagen, Cell Mol Life Sciences, 2019, 76: 3449-3464 (第一通讯作者) .
9. Chang Kong; Hao Xie; Zhenxing Gao; Ming Shao; Huan Li; Run Shi; Lili Cai; Shanshan Gao; Taolei Sun; Chaoyang Li #,Binding between Prion Protein and Aβ Oligomers Contributes to Pathogenesis of Alzheimer’s Disease. Virologica Sinica, 2019, 34： 475-488 (通讯作者).
10. Zhenxing Gao*, Min Peng*, Liang Chen, Xiaowen Yang, Huan Li, Run Shi, Guiru Wu, Lili Cai, Qibin Song, Chaoyang Li#, Prion Protein Protects Cancer Cells against Endoplasmic Reticulum Stress Induced Apoptosis, Virologica Sinica, 2019, 34(2):222-234 (通讯作者).
11. Zhenxing Gao; Jing Shi; Lili Cai; Minhua Luo; BoonSeng Wong; Xiaoping Dong; Man-sun Sy; Chaoyang Li*, Prion dimer is heterogenous and is modulated by multiple negative and positive motifs. 2019, BBRC, 509（2）： 570-6 (通讯作者)
12. Huixia Zhang1,2, Chao Zhang3, Hong Tang4, Shanshan Gao1,2, Fang Sun1,2, Yuan Yang5, Weiping Zhou5, Yu Hu6, Changshu Ke6, Yu Wu6, Zeyang Ding6, Lin Guo7, Rongjuan Pei1, Xinwen Chen1, Man-Sun Sy8, Bixiang Zhang6*, Chaoyang Li1,9* CD2-associated Protein Contributes to Hepatitis C Virus Propagation and Steatosis by Disrupting Insulin Signaling, Hepatology, 2018, 68（5）： 1710-25. doi: 10.1002/hep.30073. (第一通讯作者)
13. Zhang H X., Gao S S., Pei R J., Chen X W., Li C Y*., Hepatitis C virus-induced prion protein expression facilitates hepatitis C virus replication. Virologica Sinica. 2017, 32(6):503-510. (通讯作者)
14. Gui-Ru Wu, Tian-Chen Mu, Zhen-Xing Gao, Jun Wang, Man-Sun Sy, Chao-Yang Li*. Prion protein is required for tumor necrosis factor alpha (TNFα)-triggered nuclear factor kappa B (NF-κB) signaling and cytokine production. 2017. JBC. 292 (46): 18747-59. (通讯作者)
15. Xiaowen Yang, Zhijun Chen, Lihua Zhang, Guiru Wu, Run Shi, Zhenxing Gao, Chaoyang Li*. Prion Protein Family Contributes to Tumorigenesis via Multiple Pathways. Adv Exp Med Biol, Vol. 1018, Qiliang Cai et al. (Eds): Infectious Agents Associated Cancers: Epidemiology and Molecular Biology. 2017, 1018:207-224. (通讯作者)
16. Zhang H X, Shi R, Li C*, How will prion disease evolve (in Chinese)? Chin Sci Bull, 2017, 62: 16-24. (Invited Review) (通讯作者)
17. Wang Y, Yu S, Huang D, Cui M, Hu H, Zhang L, Wang W, Parameswaran N, Jackson M, Osborne B, Bedogni B, Li C, Sy MS, Xin W, Zhou L. 2016. Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1. Am J Pathol. 2016, 186(11):2945-2956.
18. Zhenxing Gao, Huixia Zhang, Fei Hu, Liheng Yang, Xiaowen Yang, Ying Zhu, Man-Sun Sy, Chaoyang Li*. Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan, Cellular Signalling, 2016, 28(6): 652-662. (通讯作者)
19. Yang L, Gao Z, Hu L, Wu G, Yang X, Zhang L, Zhu Y, Wong BS, Xin W, Sy MS, Li C*. GPI Anchor Modification Machinery Deficiency is Responsible for the Formation of Pro-PrP in BxPC-3 and Increases Cancer Cell Motility. J Biol Chem. 2016, 291(8):3905-17. (通讯作者)
20. Yang L, Zhang Y, Hu L, Zhu Y, Sy MS, Li C*. 2014 A panel of monoclonal antibodies against the prion protein proves that there is no prion protein in human pancreatic ductal epithelial cells. Virologica Sinica. 29(4):228-36 (通讯作者).
21. Xiaowen Yang, Yan Zhang, Lihua Zhang, Tianlin He, Jie Zhang, and Chaoyang Li* 2014. Prion protein and cancers. Acta Biochim Biophys Sin. 46（6）： 431-40 (通讯作者).
22. Wei Xin, Man-sun Sy, and Chaoyang Li., 2013. Cellular Prion Protein and Cancers. In Prions and Diseases. Edited by Wen-Quan Zou and Pierluigi Gambetti. Volume 1, Physiology and Pathophysiology, 49-66.
23. Sy, M., Altekruse S., Li, C., Lynch C., Goodman, M., Hernandes B., Zhou, L., Saber, M., Hewitt, S., and Xin, W., 2012. Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository. Cancer Biomarkers. 10: 251-258.
24. Li, C*., Yu, S*., Nakamura, F., Wei, X., and Sy, M.S. 2010. Pro-prion binds FLNa facilitates its interaction with integrin b1 and contributes to melanomagenesis. Journal of Biological Chemistry 285: 30328-39 (* co-first author)
25. Li, C., Wei Xin, and Sy, M.S. 2010. Binding of filamin A to pro-prion: Is it by design or just an unfortunate blunder? Oncogene 29 (1): 5329-45.
26. Sy, MS., Li, C., Yu, S., and X, Wei. 2010. The fatal attraction between pro-prion and filamin A: Prion as a marker in human cancers. Biomarkers Med. 4(3): 453-464.
27. Li, C., Yu, S., Nakamura, F., Yin, S., Xu, J., Patrolla, A.A., Singh, N., Tartakoff, T., Abbott, D. W., X, Wei., and Sy, M.S. 2009. Binding of pro-prion to FLNa disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer. Journal of Clinical Investigation. 119 (1): 2725-2736.
28. Pham N, Yin S, Yu S, Wong P, Kang SC, Li C, Sy MS. 2008. Normal cellular prion protein with a methionine at position 129 has a more exposed helix 1 and is more prone to aggregate. Biochem Biophys Res Commun. 368(4): 875-81.
29. Yin S, Fan X, Yu S, Li C, Sy MS. 2008 Binding of recombinant but not endogenous prion protein to DNA causes DNA internalization and expression in mammalian cells. Journal Biological Chemistry. 283(37): 25446-54.
30. Li, C*., Marrelli, M*., Yan, G. & Jacobs-Lorena, M. 2008 Fitness of Anopheles stephensi transgenic mosquitoes expressing SM1 peptide under control of vitellogenin promoter. Journal of Heredity. 99：275-282 (* co-first author)
31. Yu S, Yin S, Pham N, Wong P, Kang SC, Petersen RB, Li C, Sy MS. 2008 Ligand binding promotes prion protein aggregation--role of the octapeptide repeats. FEBS Journal. 275 (22): 5564-75.
32. Chang B, Cheng X, Yin S, Pan T, Zhang H, Wong P, Kang SC, Xiao F, Yan H, Li C, Wolfe LL, Miller MW, Wisniewski T, Greene MI, Sy MS. 2007 Test for detection of disease-associated prion aggregate in the blood of infected but asymptomatic animals. Clin Vaccine Immunol. 14(1): 36-43
33. Yin, S., Nancy Pham
, Shuiliang Yu, Chaoyang Li, Poki Wong, Binggong Chang, Shin-Chung Kang, Emiliano Biasini
, Po Tien, David A. Harris, and Man-Sun Sy. 2007. Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans. Proc. Nat. Acad. Sci. 104 (18): 7546-7551.
34. Yu S, Yin S, Li C, Wong P, Chang B, Xiao F, Kang SC, Yan H, Xiao G, Tien P, Sy M.S. 2007. Aggregation of prion protein with insertion mutations is proportional to the number of inserts. Biochemical Journal. 403(2): 343-51.
35. Goh AX1, Li C, Sy MS, Wong BS2007. Altered prion protein glycosylation in the aging mouse brain. Journal of Neurochemistry. 100 (3): 841-54.
36. Li, C., Wong, P., Pan, T., Robinson, J., Xiao, F., Yin, S., Chang, B., Kang, S., Ironside, J., and Sy, M.S., 2007. Normal cellular prion protein is a ligand of selectins: binding requires Lex but is inhibited by sLex. Biochemical Journal. 406 (2): 333-41.
37. Mauro T. Marrelli, Chaoyang Li, Jason L. Rasgon and Marcelo Jacobs-Lorena 2007. Increased fitness of transgenic mosquitoes that feed on Plasmodium-infected blood. Proc. Nat. Acad. Sci. 104 (13): 5580-5583. (Co-first author, direct submission to PNAS).
38. Yin, S., Yu, S., Li, C., Wong, P., Chang, B., Xiao, F., Kang, S.C., Yan, H., Xiao, G., Grassi, J., Tien, P., and Sy, M.S. 2006. Prion proteins with insertion mutations have altered N-terminal conformation, increased ligand-binding activity and are more susceptible to oxidative attack. Journal of Biological Chemistry 281: 10698-10705.
39. Pan, T., Wong, P., Chang, B., Li, C., Li, R., Kang S.C., Robinson, J. D., Wisniewski, T., & Sy, M. S., 2005. Biochemical fingerprints of prion infection: Accumulations of aberrant full-length and N-terminally truncated PrP species are common features in mouse prion disease. Journal of Virology 79, 934-943.
40. Pan, T., Chang, B., Wong, P., Li, C., Li, R., Kang, S., Robinson, J. D., Thompsett, A., Tein, P., Yin, S., Barnard, G., McConnell, I., Brown, D., Wisniesdki, T., and Sy, M. S., 2005 An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimmers and PrPSc aggregates. Journal of Virology 79: 12355-12364.
41. Li, C., Cox-Foster, D., Gray, S. M. and Gildow, F. E. 2001. Vector specificity of Barley yellow dwarf virus (BYDV) transmission: Identification of potential cellular receptors binding BYDV-MAV in the aphid, Sitobion avenae. Virology. 286, 125-133.
教材编写：普通病毒学（第二版第16章，科学出版社， 2019.10）。
已授权专利：1. Compositions and Methods of treating cancer related application.
Man-Sun Sy, Wei Xin, Chaoyang Li, Shuiliang Yu, and Shaoman Yin.
Patent No: US 9,492,472 B2.
2.CD2AP and its associated proteins. Chaoyang Li & Huixia Zhang.
Patent No. US 11,002,729 B2. 授权日期：2021-5-11.
3. 发明专利：CD2结合蛋白（CD2AP)和其相互作用蛋白。专利号：ZL 2017 1 0448431.8. 授权日期：2020-11-3