李翠峰：男。政治面貌：群众。

办公电话：138XXXX6046，email: licuifeng@gzhmu.edu.cn

广州医科大学生命科学学院生物技术系，职称:教授，硕士研究生导师，博士后合作导师，南山学者骨干人才，呼吸疾病全国重点实验室PI。

教育经历

2007.09-2011.06 浙江大学 学士

2011.09-2018.01 中国科学院营养与健康研究所 博士（硕博连读）

浙江大学 博士

工作经历

2018.07-2020.08 广州医科大学附属肿瘤医院 助理研究员

2020.11-2025.11 清华大学 博士后/助理研究员

2025.12-至今     广州医科大学 教授（南山学者）

教学经历及成果

教授本科生课程《生科导师大讲堂》

研究方向：

新型滴鼻疫苗佐剂开发；B细胞功能调控机制及其相关疾病研究。

科研项目

1.国家重点研发计划“揭榜挂帅”项目；项目名称：新型mRNA疫苗平台体系研究(2022-01至2026-12)，课题骨干，150万。

2.广州医科大学高水平大学建设“南山学者”骨干人才启动经费（2025.12-2030.12），主持，300万。

发表文章（部分）

一作/共一论文：

1.Li C^#, Li Y^#, Zhou B^#, Li T^#, Wei X^#, Chen K, Chen W, Shi Z, Dai X, Zhang J, Yang C, Ji Z, Sun W, Gao J, Wu J, Zhao B, Min X, Li Y, Lin L, Yang W, Wang M, Liu Z, Liu Y, Zhu C, Yang B, Xu J, Yan L, Shi Y, Lu L, Zhang L, Ding Q9, Xue J, Hou B, Qi H, Liu J*,Yang Y*, Liu D*, Liu W*. Enantiomer-dependent and modification-free DNA matrix as an adjuvant for subunit vaccines against SARS-CoV-2 or pneumococcal infections. Nat Biomed Eng. 2025. (IF=27.7) 、

2.Li C^#, Wei S^#, Sun D^#, Yang Z^#, Wang Q^#, Lin H, Zhang H, Hu Y, Liu D, Ye D, Tao Y, Liu Z, Xu Z, Li B, Li L, Zhang J, Chen X, Xie N, Shi Y, Liu S, Liu Y, Jiang Y*, Zhu W*, Zhang X*. Development of RelB-targeting small-molecule inhibitors of non-canonical NF-κB signaling with antitumor efficacy. Mol Ther. 2025. (IF=12.1)

3.Li C^#, Zhao M^#, Liu X^#, Li Y^#, Xu Bi^#, Zhou L^#, Sun X^#, Sun W, Kang N, Ji Z, Li T, An H, Wang F, Wu C, Ye J, Zhang J*, Wang Q*, Zhao X*, Li Z*, and Liu W*. Ion channel TRPV2 is critical in enhancing B cell activation and function. J Exp Med. 2024. (IF=12.8)

4.Yang B^#, Zhou B^#, Li C^#, Li X, Shi Z, Li Y, Zhu Y, Zhu C, Li X, Hua Y, Pan Y, He J, Cao T, Sun Y, Liu W, Ge M, Yang Y, Dong Y*, Liu D*. A stable l-DNA hydrogel with improved stability for biomedical applications. Angew Chem Int Ed Engl. 2022. (IF=16.1)

5.Jiang Y^#, Li C^#, Wu Q^#, An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhan Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Eugene Chin Y, Hao Y, Wang F* and Zhang X*. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nat Commun. 2019. (IF=14.7)

6.Liu X^#, Li C^#, Wang Y^#, Zhang S*, Liu W*. ZEB2 drives the differentiation of age-associated B cell in autoimmune diseases. Sci Bull (Beijing). 2024. (IF=18.8)

7.Zhou B^#, Li C^#, Liu D*, Liu W*. Chemical strategies and biomedical applications of DNA hydrogels. Fundam Res. 2022. (IF=5.7)

其他论文：

8.Ji Z^#, Gao J^#, Zhang S^#, Li J^#, Wu H^#, Yao J^#, Ma X^#, Xin Y^#, Zhu Y^#, Zhao M^#, Zhao Z, Shen K, Wu T, Qian X, Wang J, An H, Li Y, Sun W, Zhao Q, Zhou X, Gao R, Duan Q, Li C, Geng X, Yang M, Xiao R, Liu J, Wang W, Wang J, Fu Y, Zhang JR, Chen X, Tong P, Cheng G, Qi H, Wu L, Zeng W, Xi Q, Zhang L, Lai Y, Yang W, Zhang Y*, Lu Q*, Liu W*. A metabolic alarmin from keratinocytes potentiates systemic humoral immunity. Nature. 2026. (IF=48.5)

9.Sun W^#, Yang T^#, Sun F^#, Liu P^#, Gao J^#, Lan X^#, Xu W^#, Pang Y, Li T, Li C, Liang Q, Chen H, Liu X, Tan W, Zhu H, Wang F, Cheng F, Zhai W, Kim HN, Zhang J, Zhang L, Lu L*, Xi Q*, Deng G*, Huang Y*, Jin X*, Chen X*, Liu W*. An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms. Nat Immunol. 2024. (IF=27.8)

10.Zhang M^#, Kang N^#, Yu X^#, Zhang X, Duan Q, Ma X, Zhao Q, Wang Z, Wang X, Liu Y, Zhang Y, Zhu C, Gao R, Min X, Li C, Jin J, Cao Q, Liu R, Bai X, Yang H, Zhao L, Liu J, Chen H, Zhang Y, Liu W*, Zheng W*. TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet's disease. Nat Commun. 2024. (IF=14.7)

11.Hu Y^#, Zhang H^#, Xie N, Liu D, Jiang Y, Liu Z, Ye D, Liu S, Chen X, Li C, Wang Q, Huang X, Liu Y, Shi Y, Zhang X*. Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. Cell Death Differ. 2022. (IF=13.7)

12.Zhang H^#, Hu Y^#, Liu D^#, Liu Z, Xie N, Liu S, Zhang J, Jiang Y, Li C, Wang Q, Chen X, Ye D, Sun D, Zhai Y, Yan X, Liu Y, Chen CD, Huang X, Eugene Chin Y, Shi Y, Wu B*, Zhang X*. The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ+CD8αα+ intestinal intraepithelial lymphocytes. Cell Death Differ. 2022. (IF=13.7)

13.Liu Z^#, Zhang H^#, Hu Y^#, Liu D, Li L, Li C, Wang Q, Huo J, Liu H, Xie N, Huang X, Liu Y, Chen C D, Shi Y and Zhang X*. Critical role of histone H3 lysine 27 demethylase Kdm6b in the homeostasis and function of medullary thymic epithelial cells. Cell Death Differ. 2020. (IF=13.7)

14.Chen X^#, Wang C^#, Jiang Y, Wang Q, Tao Y, Zhang H, Zhao Y, Hu Y, Li C, Ye D, Liu D, Jiang W, Chin E Y, Chen S, Liu Y, Wang M*, Liu S* and Zhang X*. Bcl-3 promotes Wnt signaling by maintaining the acetylation of beta-catenin at lysine 49 in colorectal cancer. Signal Transduct Target Ther. 2020. (IF=40.8)

团队介绍：

本课题组长期致力于黏膜免疫、B细胞调控及肿瘤免疫研究，主要方向为：1滴鼻疫苗佐剂开发；2衰老、SLE、AIGA等生理、病理条件下B细胞功能异常的调控机制解析；3新型肿瘤免疫疫苗及佐剂的研发。团队现有博士后1名、硕士生3名，结构精干，注重多学科交流与个性化培养。我们常年招收博士后，同时欢迎有志于免疫学研究的本科生、研究生加入团队，共同成长。