陈琳 chenlin@gzhmu.edu.cn

陈琳, 教授，博士生导师，广州医科大学南山学者骨干人才，博士毕业于中国科学院生物物理研究所，之后加入药企从事细胞治疗相关研发工作，2018年加入广州医科大学生科院。发表多篇第一作者文章，包括Journal of Hepatology, Cancer Research, American Journal of Pathology等，合计影响因子大于40分，有丰富的肿瘤免疫和细胞治疗领域研究经验，同时具备临床细胞治疗产品开发经验。

研究方向：

-宫颈癌、鼻咽癌、结肠癌等肿瘤的T细胞免疫治疗机制研究及方法开发

-免疫检查点抗体与其他治疗方法的联合用药方法开发

Publications:

1. Wang, C., Xiong, C., Hsu, Y., Wang, X., & Chen, L. (2020). Human leukocyte antigen (HLA) and cancer immunotherapy: HLA-dependent and -independent adoptive immunotherapies. Annals of Blood, 5(4), 14–14.

2. Chen, L., Li, J., Wang, F., Dai, C., Wu, F., Liu, X., Li, T., Glauben, R., Zhang, Y., Nie, G., He, Y., & Qin, Z. (2016). Tie2 expression on macrophages is required for blood vessel reconstruction and tumor relapse after chemotherapy. Cancer Research, 76(23), 6828–6838. （IF=12.7）

3. Chen, L., Li, J., Zhang, J., Dai, C., Liu, X., Wang, J., Gao, Z., Guo, H., Wang, R., Lu, S., Wang, F., Zhang, H., Chen, H., Fan, X., Wang, S., & Qin, Z. (2015). S100A4 promotes liver fibrosis via activation of hepatic stellate cells. Journal of Hepatology, 62(1), 156–164. （IF=25.08）

4. Li, Q., Dai, C., Xue, R., Wang, P., Chen, L., Han, Y., Erben, U., & Qin, Z. (2018). S100A4 protects myeloid-derived suppressor cells from intrinsic apoptosis via TLR4-ERK1/2 signaling. Frontiers in Immunology, 9, 1–14. （IF=5.08）

5. Sun, L., Sun, C., Liang, Z., Li, H., Chen, L., Luo, H., Zhang, H., Ding, P., Sun, X., Qin, Z., & Zhao, Y. (2015). FSP1+fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells. Scientific Reports, 5, 1–16. （IF=4.13）

6. Zhang, J., Chen, L., Liu, X., Kammertoens, T., Blankenstein, T., & Qin, Z. (2013). Fibroblast-specific protein 1/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens. Cancer Research, 73(9), 2770–2781. （IF=12.7）

7. Zhang, J., Chen, L., Xiao, M., Wang, C., & Qin, Z. (2011). FSP1+fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation. American Journal of Pathology, 178(1), 382–390. （IF=3.52）

8. Li, Z., Chen, L., & Qin, Z. (2009). Paradoxical Roles of IL-4 in Tumor Immunity The paradox of IL-4 in tumor immunity. Cellular & Molecular Immunology, 2. （IF=11.53）

9. 李懿,陈琳编著.《人类白细胞抗原》.科学出版社.2018年3月出版.

科研项目：

1. 国自然青年基金：针对中国人群中HPV阳性宫颈癌的T细胞治疗靶点发现及其靶向治疗研究. 2020-2022. 在研

2. 广州医科大学人才引进项目启动经费：2018-2023. 在研