刘恒：男，中共党员。

办公电话：email: hengliu@gzhmu.edu.cn

广州医科大学生命科学学院，教授，博士/硕士研究生导师。入选2022年海外高层次青年人才项目，南山学者“第三层次”领军人才。

教育经历

2003-2007 中国科学技术大学 学士

2007-2014 中国科学技术大学 博士

 

工作经历

2015-2017 美国匹兹堡大学 研究助理

2018-2022 美国匹兹堡大学 博后

2022-至今 广州医科大学 教授

 

研究方向

重要药物靶点G蛋白偶联受体（GPCR）结构药理学研究及创新药物研发

 

发表文章（部分）

 

1. Qi, X. *, Liu, H.*, Thompson, B., McDonald, J., Zhang, C., & Li, X. Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi. Nature. (2019). (*Equal contribution)

2. Liu, H., H.R. Kim, R.N.V.K. Deepak, L. Wang, K.Y. Chung, H. Fan, Z. Wei, C. Zhang, Orthosteric and allosteric action of the C5a receptor antagonists. Nat. Struct. Mol. Biol. (2018).

3. Liu,H., Dapeng Sun, Alexander Myasnikov, Marjorie Damian, Jean-Louis Baneres, Ji Sun, Cheng Zhang. Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren. Nat Commun. (2021).

4. Liu,H.*, R.N.V.K. Deepak*, Anna Shiriaeva*, Cornelius Gati, Alexander Batyuk, Hao Hu, Uwe Weierstall, Wei Liu, Lei Wang, Vadim Cherezov, Hao Fan, Cheng Zhang, Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2. PNAS. (2021). (*Equal contribution)

5. Zhuang, Y*., Liu, H.*, Edward Zhou, X., Verma, R., de Waal, P., Jang, W., Xu, T., Wang, L., Meng, X., Zhao, G., Kang, Y., Melcher, K., Fan, H., Lambert, N., Xu, H. E., Zhang, C. Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling. Nat Commun. (2020). (*Equal contribution)

6. A. Dumitru*, KRNV Deepak*, Liu, H.*, M. Koehler, C. Zhang, H. Fan, D. Alsteens. Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism. Communications Biology. (2020). (*Equal contribution)