徐玮
办公电话：130xxxx3962，email: xuwei2023@gzhmu.edu.cn
广州医科大学生命科学学院，生技教研室，硕士研究生导师，“南山学者”骨干人才。
教育经历
2009.09-2013.06 武汉大学 学士
2013.09-2018.12 武汉大学 博士
工作经历
2019.03 - 2019.06 深圳迈瑞生物医疗电子股份有限公司 试剂研发工程师
2019.08 - 2022.01 南方科技大学 博士后
2022.02 - 2023.03 南方科技大学 研究助理教授
2023.04 - 至今 广州医科大学 南山学者特聘教授
研究方向：
1. Simple, robust and flexible single cell epigenetic and transcriptomic methods development.
We are developing simple, robust and flexible methods that can be done in a plate-based small-scale format and in a high-throughput format. They have different pros and cons, but both are essential for the research. By combining upfront mini-bulk reaction with single cells or single nuclei isolation, we have developed a few methods that allow us profiling chromatin status and gene expression in a straightforward and economical way.
2. Mechanistic Insights into Chromosome Structure Maintenance Complex SMC5/6.
The cohesin- and condensin-related SMC5/6 complex restricts transcription of foreign episomal/viral DNA in the cell nucleus, distinguishing itself from other family complexes. We are interested in its potential role in inhibiting endogenous extrachromosomal circular DNA (eccDNA) and DNA viruses.
主持项目
1. 国家自然科学基金委员会, 青年科学基金项目, 32200509，PJA1调控染色体结构维持复合物SMC5/6抑制eccDNA原癌基因转录的机制探索，2023.01-2025.12，主持，30 万元，在研。
2. 广州医科大学高水平大学建设南山学者骨干人才启动经费，2023.04-2028.04，主持，200万元，在研。
发表文章（部分）
1. Wei Xu#, Weilong Yang#, Yunlong Zhang, Yawen Chen, Qian Zhang, Xuefei Wang, Kun song, Wenfei Jin*, Xi Chen*, ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells, Nature Methods, 2022. (期刊论文，IF=47.99)
2. Wei Xu, Yi Wen, Yingying Liang, Qiushi Xu, Xuefei Wang, Wenfei Jin and Xi Chen*; A plate-based single cell ATAC-seq method for fast and robust profiling of chromatin accessibility, Nature Protocol, 2021. (期刊论文，IF=17.02)
3. Wei Xu#; Ying Ye#; Andrew D. Sharrocks; Wensheng Zhang*; Xi Chen*; Genome-wide Interrogation of Protein-DNA Interactions in Mammalian Cells Using ChIPmentation, STAR Protocols, 2020, 3(1): 100187-100187. (期刊论文)
4. Xu, Wei; Ma, Chunqiang; Zhang, Qi; Zhao, Rong; Hu, Dan; Zhang, Xuewu; Chen, Junbo; Liu, Fang; Wu, Kailang; Liu, Yingle*; Wu, Jianguo*; PJA1 Coordinates with the SMC5/6 Complex To Restrict DNA Viruses and Episomal Genes in an Interferon-Independent Manner , Journal of Virology, 2018, 92(22):e00825-18. (期刊论文, IF=6.54)
5. Ma, Chunqiang; Xu, Wei; Yang, Qingyu; Liu, Weiyong; Xiang, Qi; Chen, Junbo; Zhang, Qi; Liu, Yingle; Wu, Kailang*; Wu, Jianguo*; Osteopetrosis-Associated Transmembrane Protein 1 Recruits RNA Exosome To Restrict Hepatitis B Virus Replication. , Journal of Virology, 2020, 94(11): e01800-19. (期刊论文)